지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 285 - 293 (9page)
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초록· 키워드
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Purpose: The incidence and clinical correlation of MALT1 translocation and chromosomal numerical aberrations in Korean patients with ocular adnexal mucosa associated lymphoid tissue (MALT) lymphoma have not yet been reported. We investigated the incidence and clinicopathologic relationship of these chromosomal aberrations in ocular adnexal MALT lymphomas in a Korean population.
Methods: Thirty ocular adnexal MALT lymphomas were investigated for the t(11;18) API2-MALT1, t(14;18) IgHMALT1 translocations and chromosomes 3 and 18 aneuploidies using fluorescence in situ hybridization. Patient medical records were reviewed retrospectively for information on demographics and clinical characteristics, including treatment response.
Results: The MALT1 gene rearrangement was found in one out of 30 cases. The t(14;18) IgH-MALT1 translocation was demonstrated in only one case (3.3%), and the t(11;18) API2-MALT1 translocation was not found in any of the cases. Trisomy 3 was observed in three ocular adnexal MALT lymphomas (10.0%), and five cases showed trisomy 18 (16.7%). Translocation positive cases also showed trisomy 18. One case of tumor relapse showed trisomy 18 only in the recurrent biopsies. There were no statistically significant correlations between chromosomal aberrations and clinical characteristics and treatment responses.
Conclusions: Translocations involving the MALT1 gene are not common in Korean ocular adnexal MALT lymphomas.
The t(14;18) translocation was detected in only one out of 30 cases, and the t(11;18) translocation was not found at all. Furthermore, the chromosomal aberrations found in this study had no prognostic implications.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Akagi T / 1999 / A novel gene, MALT1at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissue / Oncogene 18 : 5785
Cho EY / 2003 / Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone b-cell lymphoma constitutes the vast majority of ocular lymphomas among Korea
Choung HK / 2012 / Multigene methylation analysis of ocular adnexal MALT lymphoma and their relationship to Chlamydophila psittaci infection and clinical characteristics in S
Coupland SE / 2002 / Ocular adnexal lymphomas:five case presentations and a review of the literature / Surv Ophthalmol 47 : 470 ~ 490
Du MQ / 2006 / Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management / Gut 55 : 886 ~ 893
Cho EY / 2003 / Clinicopathologic analysis of ocular adnexal lymphomas: extranodal marginal zone b-cell lymphoma constitutes the vast majority of ocular lymphomas among Korea
Choung HK / 2012 / Multigene methylation analysis of ocular adnexal MALT lymphoma and their relationship to Chlamydophila psittaci infection and clinical characteristics in S
Coupland SE / 2002 / Ocular adnexal lymphomas:five case presentations and a review of the literature / Surv Ophthalmol 47 : 470 ~ 490
Du MQ / 2006 / Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management / Gut 55 : 886 ~ 893
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