지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 320 - 324 (5page)
이용수
초록· 키워드
오류제보하기
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a drug hypersensitivity syndrome characterized by fever, skin rash, blood eosinophilia and multiple organ involvements including liver and kidney developed following drug administration. Vasculitis could be infrequent one of manifestations of DRESS syndrome.
Mortality rate of DRESS syndrome is at least 10%. Here,we reported a case of DRESS syndrome with vasculitis. A 67-year-old man with essential hypertension presented with fever and maculopapular rash after being given allopurinol over 2 weeks for gout. He had severe oral mucositis. He had peripheral blood eosinophilia and abnormal hepatic and renal functions. A skin biopsy showed leukocytoclastic vasculitis. Gastroduodenoscopy showed spontaneous mucosal oozing in mid-to-lower esophagus. He was diagnosed as having DRESS syndrome with vasulitis. Allopurinol was stopped and systemic corticosteroid was administrated. His clinical manifestations improved gradually. However, he died of sudden onset of massive intracranial hemorrhage.
The case suggests that DRESS syndrome could sometimes present manifestations of vasculitis, which might be fatal.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Arellano F / 1993 / Sacristan JA. Allopurinol hypersensitivity syndrome / Ann Pharmacother 27 : 337 ~ 43
Begon E / 2004 / Hypersensitivity syndrome: DRESS (drug rash with eosinophilia and systemic symptoms) / Ann Dermatol Venereol 131 : 293 ~ 7
Bocquet H / 1996 / Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms: DRESS). / Semin Cutan Med Surg 15 : 250
Calabrese LH / 1997 / Vasculitis in the central nervous system / Arthritis Rheum 40 : 1189 ~ 201
Chan YC / 2002 / Allopurinol hypersensitivity syndrome and acute myocardial infarction / Ann Acad Med Singapore 31 : 231 ~ 3
Begon E / 2004 / Hypersensitivity syndrome: DRESS (drug rash with eosinophilia and systemic symptoms) / Ann Dermatol Venereol 131 : 293 ~ 7
Bocquet H / 1996 / Drug-induced pseudolymphoma and drug hypersensitivity syndrome (drug rash with eosinophilia and systemic symptoms: DRESS). / Semin Cutan Med Surg 15 : 250
Calabrese LH / 1997 / Vasculitis in the central nervous system / Arthritis Rheum 40 : 1189 ~ 201
Chan YC / 2002 / Allopurinol hypersensitivity syndrome and acute myocardial infarction / Ann Acad Med Singapore 31 : 231 ~ 3
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