지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 241 - 247 (7page)
이용수
초록· 키워드
오류제보하기
Purpose: To determine whether topical tacrolimus might prove effective in the treatment of refractory anterior segment inflammatory diseases, and to evaluate its efficacy in eyes with ocular graft versus host disease (GVHD), and vernal keratoconjunctivitis (VKC).
Methods: Twenty-eight eyes of 14 patients with anterior segment inflammation refractory to steroid treatment were treated with 0.03% tacrolimus ointment at the Samsung Medical Center, Seoul, Korea from March 2008 through August 2009. Seven patients had ocular GVHD and seven had VKC. We evaluated the conjunctival and corneal inflammatory change at one, two, four, and eight weeks after treatment with a scoring system. Time to initial response of treatment and therapeutic effect between GVHD and VKC was also analyzed. After the eight-week treatment period, patients were divided into two groups (maintenance group and discontinuance group). Eight patients maintained the treatment for an additional four months, and six patients discontinued the treatments. Therapeutic effect was also compared between the groups at eight weeks and six months after treatment.
Results: The mean conjunctival and corneal inflammation score was reduced significantly at eight weeks after treatment (p < 0.0001). The therapeutic effect in conjunctival inflammation was first noted at week two after the initial treatment (p = 0.002); reduction in corneal inflammation was first noted at one week (p = 0.0009). When compared according to diagnosis, no therapeutic difference was detected between the groups (p > 0.05). Six months after treatment, we noted no therapeutic differences between the maintenance group and discontinuance group (p > 0.05).
Conclusions: 0.03% tacrolimus ointment was safe and effective for use in anterior segment inflammatory disease refractory to steroid.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bhorade SM / 2003 / Comparison of three tacrolimus-based immunosuppressive regimens in lung transplantation / Am J Transplant 3 : 1570 ~ 1575
Crespo-Leiro MG / 2003 / Tacrolimus in heart transplantation / Transplant Proc 35 : 1981 ~ 1983
Dhaliwal JS / 2008 / Long-term use of topical tacrolimus (FK506) in high-risk penetrating keratoplasty / Cornea 27 : 488 ~ 493
Frandsen E / 1996 / Glaucoma and cataract as complications to topical steroid therapy / Acta Ophthalmol (Copenh) 44 : 307 ~ 312
Glynne R / 2000 / How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis / Nature 403 : 672 ~ 676
Crespo-Leiro MG / 2003 / Tacrolimus in heart transplantation / Transplant Proc 35 : 1981 ~ 1983
Dhaliwal JS / 2008 / Long-term use of topical tacrolimus (FK506) in high-risk penetrating keratoplasty / Cornea 27 : 488 ~ 493
Frandsen E / 1996 / Glaucoma and cataract as complications to topical steroid therapy / Acta Ophthalmol (Copenh) 44 : 307 ~ 312
Glynne R / 2000 / How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis / Nature 403 : 672 ~ 676
이 논문의 저자 정보
최근 본 자료
댓글(0)
0