지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 101 - 107 (7page)
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초록· 키워드
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Purpose: To investigate the effect of catechin on apoptotic cell death in the lens epithelium of rats with cataract.
Methods: Cataract was induced by intraperitoneal injection of 100 mg/kg N-methyl-N-nitrosourea (MNU) to ten day-old Sprague-Dawley rats. The neonatal rats were randomly divided into five groups (n=15 in each group): a control group, and four cataract-induction groups, treated with either 0, 50, 100, 200 mg/kg catechin. We performed slit-lamp biomicroscopic analysis, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, Western-blot for Bcl-2 and Bax, and immunohistochemistry for caspase-3.
Results: Apoptotic cell death in lens epithelial cells that increased following cataract formation in rats was suppressed by cathechin.
Conclusions: Catechin inhibited cataract-induced apoptotic cell death in the lens epithelium and may prove useful for the prevention of cataract progression.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Anjaneyulu M / 2003 / Attenuation of cyclosporine-induced renal dysfunction by catechin: possible antioxidant mechanism / Ren Fail 25 : 691 ~ 707
Bassnett S / 1994 / Intercellular co- mmunication between epithelial and fiber cells of the eye lens / Cell Sci 107 : 799 ~ 811
Berletch JB / 2008 / Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG / J Cell Biochem 103 : 509 ~ 519
Bun SS / 2006 / Effect of green tea extracts on liver functions in Wistar rats / Food Chem Toxicol 44 : 1108 ~ 1113
Charakidas A / 2005 / Lens epithelial apoptosis and cell proliferation in human age-related cortical cataract / Eur J Ophthalmol 15 : 213 ~ 220
Bassnett S / 1994 / Intercellular co- mmunication between epithelial and fiber cells of the eye lens / Cell Sci 107 : 799 ~ 811
Berletch JB / 2008 / Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG / J Cell Biochem 103 : 509 ~ 519
Bun SS / 2006 / Effect of green tea extracts on liver functions in Wistar rats / Food Chem Toxicol 44 : 1108 ~ 1113
Charakidas A / 2005 / Lens epithelial apoptosis and cell proliferation in human age-related cortical cataract / Eur J Ophthalmol 15 : 213 ~ 220
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