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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 43 - 50 (8page)
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초록· 키워드
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Background: Houttuynia cordata has long been used in traditional oriental medicine for the treatment of inflammatory disease. In the present study, we investigated the anti-inflammatory effect of Houttuynia cordata extracts on Raw 264.7 cells, which is activated with lipopolysaccharide (LPS) and interferon-γ (IFN-γ).
Methods: We treated LPS-and IFN-γ-activated murine macrophage Raw 264.7 cells with extracts of Houttuynia cordata and measured the production of nitric oxide (NO) and prostaglandin E2 (PGE2), and the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, and pro-inflammatory cytokines (Interleukin [IL]-1α, IL-1β, IL-4, IL-6, IL-10, IL-12, tumor necrosis factor-α, regulated on activation normal T-cell expressed and secreted) in activated Raw 264.7 cells after treatment with Houttuynia cordata extracts. Results: NO formation by activated Raw 264.7 cells was reduced in response to Houttuynia Cordata in a dose-dependent manner. Formation of PGE2, a final product of the COX pathway was reduced by Houttuynia cordata extracts and reduction in COX-2 expression was proportional to the reduction in PGE2. The expression of proteins, iNOS and COX-2 decreased with increasing concentration of Houttuynia cordata extracts. The related pro-inflammatory cytokines did not decrease in the cells treated with Houttuynia cordata extracts. Conclusion: Houttuynia Cordata extracts suppressed the production of NO and PGE2 and decreased the expression of iNOS and COX-2. It has potential for the treatment of inflammatory diseases. Further studies are needed to elucidate the effects of Houttuynia Cordata extracts on the production of inflammatory cytokines.
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참고문헌 (23)
참고문헌 신청
Aktan F / 2004 / iNOS-mediated nitric oxide production and its regulation / Life Sci 75 : 639 ~ 653
Choi YH / 1994 / Antimutagenic effects of the juice and boiling water extract of Houttuynia cordata Thunb / J Korean Soc Food Sci Nutr 23 : 916 ~ 921
Chou SC / 2009 / The constituents and their bioactivities of Houttuynia cordata / Chem Pharm Bull(Tokyo) 57 : 1227 ~ 1230
Chung CK / 1999 / Effect of Houttuynia cordata ethanol extracts on serum lipids and antioxidant enzymes in rat fed high fat diet / J Korean Soc Food Sci Nutr 28 : 205 ~ 211
Coruzzi G / 2007 / Gastrointestinal safety of novel nonsteroidal antiinflammatory drugs: selective COX-2 inhibitors a
Choi YH / 1994 / Antimutagenic effects of the juice and boiling water extract of Houttuynia cordata Thunb / J Korean Soc Food Sci Nutr 23 : 916 ~ 921
Chou SC / 2009 / The constituents and their bioactivities of Houttuynia cordata / Chem Pharm Bull(Tokyo) 57 : 1227 ~ 1230
Chung CK / 1999 / Effect of Houttuynia cordata ethanol extracts on serum lipids and antioxidant enzymes in rat fed high fat diet / J Korean Soc Food Sci Nutr 28 : 205 ~ 211
Coruzzi G / 2007 / Gastrointestinal safety of novel nonsteroidal antiinflammatory drugs: selective COX-2 inhibitors a
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