지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 34 - 42 (9page)
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초록· 키워드
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Background: Lung functions in asthmatics may depend on various factors: reversible airway obstruction, irreversible airway obstruction associated with airway remodeling, more rapid decline in lung functions than non-asthmatics, and medication effect on decline in lung functions. This study aimed to investigate longitudinal changes in lung functions in adult asthmatics.
Methods: Fifty-one adult asthmatics were included in the study. Their medical records were retrospectively reviewed. Lung functions were obtained at baseline, and visits 1, 2, 3 and 4, with intervals of 10∼15 months. Asthmatics were classified into those with forced expiratory volume in 1 second (FEV_1)≥80% predicted (normal lung function) and those with FEV_1＜80% (decreased lung function) in reference to baseline lung functions.
Results: Annual decline rates of FEV_1 were −12.4±10.1 mL/yr in all asthmatics, −25.9±12.6 mL/yr in asthmatics with normal lung functions, and 14.7±13.8 mL/yr in asthmatics with decreased lung functions. FEV1 did not significantly change at visits 1, 2, 3 and 4 compared to the baseline value in all asthmatics and asthmatics with normal or decreased lung functions. FEV_1 values at visits 1, 2, 3, and 4 decreased only in 8.3%∼18.2% of asthmatics with normal lung functions and normalized only in 16.7%∼30% of asthmatics with decreased lung functions.
Conclusion: In adult asthmatics treated with medications, irreversible airway obstruction may not occur in those with normal lung functions, while reduced functions may not normalize in those with decreased lung functions, in whom airway remodeling may have occurred early in the disease state.
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참고문헌 (25)
참고문헌 신청
Bateman ED / 2004 / GOAL Investigators Group. Can guideline- defined asthma control be achieved? The Gaining Optimal Asthma ControL study / Am J Respir Crit Care Med 170 : 83
Busse WW / 2001 / Asthma / N Engl J Med 344 : 350 ~ 362
Busse WW / 2008 / START Investigators Group. The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow- up: effectiveness of early interve
Dijkstra A / 2006 / Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex / Thorax 61 : 105 ~ 110
Guilbert TW / 2006 / Long-term inhaled corticosteroids in preschool children at high risk for asthma / N Engl J Med 354 : 1985 ~ 1997
Busse WW / 2001 / Asthma / N Engl J Med 344 : 350 ~ 362
Busse WW / 2008 / START Investigators Group. The Inhaled Steroid Treatment As Regular Therapy in Early Asthma (START) study 5-year follow- up: effectiveness of early interve
Dijkstra A / 2006 / Lung function decline in asthma: association with inhaled corticosteroids, smoking and sex / Thorax 61 : 105 ~ 110
Guilbert TW / 2006 / Long-term inhaled corticosteroids in preschool children at high risk for asthma / N Engl J Med 354 : 1985 ~ 1997
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