지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 199 - 206 (8page)
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Background: Portulaca oleracea L. is known to have detoxification and antibacterial effects. Inflammatory responses in LPS-treated Raw264.7 cells include the secretions of NO,PGE2 and numerous cytokines. Atopic dermatitis is a chronic inflammatory skin disease. This study was performed to identify the antiinflammatory or anti-pruritic effects of Portulaca oleracea L. extract in LPS-treated Raw264.7 cells and keratinocytes and the skin of NC/Nga mice with atopic dermatitis, as well as hairless mice with pruritus.
Methods: After the treatment of different concentrations for Portulaca oleracea L. extract in LPS-treated Raw264.7 cells and keratinocytes, the levels of NO, PGE2 and proinflammatory cytokines were measured in the media. Skin tissues of all Nc/Nga mice were subjected to H&E staining and toluidine blue staining. An antipruritic effect was defined as the number of scratching behaviors of the hairless SKH-1 mice treated with compound 48/80.
Results: LPS- and IFN-γ-treated Raw264.7 cells decreased NO and PGE2 productions compared to non-treated Raw264.7cells. H&E or toluidine blue staining revealed that the thicknesses of the epidermis and dermis were reduced in NC/Nga mice with atopic dermatitis treated with Portulaca oleracea L. extract. However, Itching behaviors in hairless mice treated with Portulaca oleracea L. extract were not decreased compared to non-treated hairless mice.
Conclusion: The results of this study suggest that Portulaca oleracea L. extract could be a new therapeutic agent for atopic dermatitis.
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참고문헌 (28)
참고문헌 신청
Allen LA / 1996 / Mechanisms of phagocytosis / Curr Opin Immunol 8 : 36 ~ 40
Bhattacharyya A / 2002 / Mitogen-activated protein kinases and nuclear factor- kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages / Biochem
Blichmann CW / 1988 / Assessment of skin moisture. Measurement of electrical conductance, capacitance and transepidermal water loss / Acta Derm Venereol 68 : 284 ~ 290
Chan K / 2000 / The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. sativa (Haw.) Celak / J Ethnopharmacol 73 : 445 ~ 451
Chen CJ / 2009 / Anti-hypoxic activity of the ethanol extract from Portulaca oleracea in mice / J Ethnopharmacol 124 : 246 ~ 250
Bhattacharyya A / 2002 / Mitogen-activated protein kinases and nuclear factor- kappaB regulate Helicobacter pylori-mediated interleukin-8 release from macrophages / Biochem
Blichmann CW / 1988 / Assessment of skin moisture. Measurement of electrical conductance, capacitance and transepidermal water loss / Acta Derm Venereol 68 : 284 ~ 290
Chan K / 2000 / The analgesic and anti-inflammatory effects of Portulaca oleracea L. subsp. sativa (Haw.) Celak / J Ethnopharmacol 73 : 445 ~ 451
Chen CJ / 2009 / Anti-hypoxic activity of the ethanol extract from Portulaca oleracea in mice / J Ethnopharmacol 124 : 246 ~ 250
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