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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 163 - 168 (6page)
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초록· 키워드
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Purpose: To evaluate the inhibitory effect of chlorogenic acid on laser‐induced choroidal neovascularization (CNV) in a rat model.
Methods: Intraperitoneal injection of chlorogenic acid (10 mg/kg) was inititated one day prior to laser photocoagulation and continued for eight days. Eyes were removed 14 days after laser photocoagulation. Fluorescein angiography was employed at seven and 14 days to assess the CNV lesions, and histological examination was performed. Quantification of CNV size and leakage were performed both in histological sections and fluorescein angiography in order to compare the inhibitory effects of chlorogenic acid on CNV with the results of the control.
Results: Histological analysis showed no significant difference in CNV size between the treated and control groups. However, CNV leakage on fluorescein angiography had significantly decreased in the chlorogenic acid‐treated group at 14 days after laser photocoagulation compared with that of the control group. In addition, CNV size on fluorescein angiography had significantly decreased in the treated group at seven and 14 days.
Conclusions: These results suggest that chlorogenic acid has anti‐angiogenic effects on CNV and may be useful as an inhibitor in the treatment or prevention of neovascular age‐related macular degeneration.
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참고문헌 (25)
참고문헌 신청
Adamis AP / 2005 / The role of vascular endothelial growth factor in ocular health and disease / Retina 25 : 111 ~ 118
Arts IC / 2005 / Polyphenols and disease risk in epidemiologic studies / Am J Clin Nutr 81 : 317S ~ 325S
Beatty S / 2000 / The role of oxidative stress in the pathogenesis of age-related macular degeneration / Surv Ophthalmol 45 : 115 ~ 134
Carmeliet P / 1999 / Developmental biology. Controlling the cellular brakes / Nature 401 : 657 ~ 658
Chinnici F / 2004 / Radical scavenging activities of peels and pulps from cv. Golden Delicious apples as related to their phenolic composition / J Agric Food Chem 52 : 4684
Arts IC / 2005 / Polyphenols and disease risk in epidemiologic studies / Am J Clin Nutr 81 : 317S ~ 325S
Beatty S / 2000 / The role of oxidative stress in the pathogenesis of age-related macular degeneration / Surv Ophthalmol 45 : 115 ~ 134
Carmeliet P / 1999 / Developmental biology. Controlling the cellular brakes / Nature 401 : 657 ~ 658
Chinnici F / 2004 / Radical scavenging activities of peels and pulps from cv. Golden Delicious apples as related to their phenolic composition / J Agric Food Chem 52 : 4684
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