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논문 기본 정보

자료유형
학술저널
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저널정보
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제28권 제5호
발행연도
2014.1
수록면
386 - 392 (7page)

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Purpose: To investigate which spectral domain optical coherence tomography (SD-OCT) findings predict visual outcome after anti-vascular endothelial growth factor (VEGF) treatment in neovascular age-related macular degeneration (NV-AMD). Methods: We reviewed the medical records of patients with treatment-naïve NV-AMD who underwent three or more consecutive anti-VEGF injections. The patients were divided into three groups according to their changes of visual acuity (VA); improved (group I), static (group S), or worsened (group W). We assessed the incidences and values of all available SD-OCT findings of these groups, compared these findings between the three groups and compared the initial values with the post-treatment values. Results: Better initial VA and longer external limiting membrane (ELM) length were associated with less change in VA after anti-VEGF treatment. The initial VA was mildly correlated with initial photoreceptor inner and outer segment junction (IS/OS) length and initial ELM length. The final VA was also mildly correlated with the final IS/ OS length and the final ELM length. VA was significantly changed after anti-VEGF treatment in groups W and I. With regard to incidence, disruption of the IS/OS (IS/OS-D), disruption of the ELM (ELM-D) and ELM length differed significantly between the three groups, particularly ELM-D. The incidences of IS/OS-D and ELM-D in group I were significantly lower than those in groups S and W, and those in group S were also lower than those in group W. The ELM length in group I was significantly longer than it was in groups S and W, and the ELM length in group S was longer than that for group W. However, these three findings did not change after the anti-VEGF treatment. Conclusions: Initial IS/OS-D, ELM length and particularly ELM-D can be useful predictors of the visual outcome after anti-VEGF treatment in NV-AMD patients.
#Choroidal neovascularization #Macular degeneration #Optical coherence tomography

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참고문헌 (13)

참고문헌 신청
/ 1999 / Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin:one-year results of 2 randomized clinical trials: google schola Bressler NM / 2001 / Photodynamic therapy of subfoveal choroidal neovascularization in age-related macular degeneration with verteporfin:two-year results of 2 randomized clin google schola Dadgostar H / 2008 / The evolving role of vascular endothelial growth factor inhibitors in the treatment of neovascular age-related macular degeneration / Eye 22 : 761 ~ 767 google schola Hagan MJ / 1971 / Histology of the human eye: an atlas and textbook / Saunders : 393 ~ 522 google schola Hayashi H / 2009 / Association between foveal photoreceptor integrity and visual outcome in neovascular age-related macular degeneration / Am J Ophthalmol 148 : 83 ~ 89e1 google schola

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