메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
저널정보
대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제28권 제1호
발행연도
2014.1
수록면
76 - 82 (7page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Purpose: In Asian countries, laser iridotomy for the treatment of angle-closure glaucoma is a common cause ofbullous keratopathy, which may be associated with a shallow anterior chamber and dark iris pigmentation inAsians. Several cases of corneal decompensation after argon laser iridotomy have been reported. In the presentstudy, we evaluated the harmful effects of argon laser iridotomy on the corneal endothelium. Methods: Argon laser iridotomy was performed on the right eyes of pigmented rabbits. Changes in cornealthickness and endothelial cell density after laser iridotomy were evaluated. Terminal deoxynucleotidyl transferasedUTP nick end labeling (TUNEL) was performed for assessment of corneal endothelial cell apoptosis. Combined staining with alizarin red and trypan blue, as well as a live/dead cell assay, were performed for evaluationof damage to the corneal endothelium induced by laser iridotomy. Results: Corneal thickness did not change immediately after laser iridotomy; however, a significant increasewas observed 24 hours after iridotomy (p = 0.001). The endothelial cell density of laser-treated eyes four daysafter laser iridotomy was significantly decreased compared with control eyes (p < 0.001). TUNEL stainingshowed many TUNEL-positive cells in the corneal endothelium and corneal stroma. No endothelial trypanblue-stained cell nuclei were observed after laser iridotomy; however, several large endothelial cells with damagedmembrane integrity were observed. The live/dead cell assay clearly showed a large number of deadcells stained red in several areas throughout the entire corneal button 24 hours after iridotomy. Conclusions: Argon laser iridotomy induces corneal endothelial cell apoptosis in pigmented rabbit eyes, resultingin decreased endothelial cell density.

목차

등록된 정보가 없습니다.

참고문헌 (27)

참고문헌 신청

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0