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학술저널
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대한안과학회 Korean Journal of Ophthalmology Korean Journal of Ophthalmology 제31권 제1호
발행연도
2017.1
수록면
71 - 79 (9page)

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Purpose: The purpose of this study was to demonstrate whether the pattern of optic nerve enhancement inmagnetic resonance imaging (MRI) can help to differentiate between idiopathic optic neuritis (ON), neuromyelitisoptica (NMO), and multiple sclerosis (MS) in unilateral ON. Methods: An MRI of the brain and orbits was obtained in patients with acute unilateral ON. Patients with ONwere divided into three groups: NMO, MS, and idiopathic ON. The length and location of the abnormal opticnerve enhancement were compared for ON eyes with and without NMO or MS. The correlation between thepattern of optic nerve enhancement and the outcome of visual function was analyzed. Results: Of the 36 patients with ON who underwent an MRI within 2 weeks of the onset, 19 were diagnosedwith idiopathic ON, 9 with NMO, and 8 with MS. Enhancement of the optic nerve occurred in 21 patients(58.3%)and was limited to the orbital segment in 12 patients. Neither the length nor the location of the optic nerve enhancementwas significantly correlated with visual functions other than contrast sensitivity or the diagnosis ofidiopathic ON, MS, or NMO. Patients with greater extent of optic nerve sheath enhancement and more posteriorsegment involvement showed higher contrast sensitivity. Conclusions: Our data revealed that the pattern of optic nerve enhancement was not associated with diagnosisof idiopathic ON, NMO, or MS in Korean patients with unilateral ON. We believe further studies that includedifferent ethnic groups will lead to a more definitive answer on this subject.

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