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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 131 - 137 (7page)
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초록· 키워드
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Purpose: To investigate the therapeutic effects of mineral oil (MO) and hyaluronic acid (HA) mixture eye drops on the tear film and ocular surface in a mouse model of experimental dry eye (EDE).
Methods: Eye drops consisting of 0.1% HA alone or mixed with 0.1%, 0.5%, or 5.0% MO were applied to desiccating stress-induced murine dry eyes. Tear volume, corneal irregularity score, tear film break-up time (TBUT), and corneal fluorescein staining scores were measured at 5 and 10 days after treatment. Ten days after treatment, goblet cells in the conjunctiva were counted after Periodic acid-Schiff staining.
Results: There was no significant difference in the tear volume between desiccating stress-induced groups.
The corneal irregularity score was lower in the 0.5% MO group compared with the EDE and HA groups. The 0.5% and 5.0% MO groups showed a significant improvement in TBUT compared with the EDE group. Mice treated with 0.1% and 0.5% MO mixture eye drops showed a significant improvement in fluorescein staining scores compared with the EDE group and the HA group. The conjunctival goblet cell count was higher in the 0.5% MO group compared with the EDE group and HA group.
Conclusions: The MO and HA mixture eye drops had a beneficial effect on the tear films and ocular surface of murine dry eye. The application of 0.5% MO and 0.1% HA mixture eye drops could improve corneal irregularity, the corneal fluorescein staining score, and conjunctival goblet cell count compared with 0.1% HA eye drops in the treatment of EDE.
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
/ 2007 / The definition and classification of dry eye disease / report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop 5 : 75 ~ 92
Behrens A / 2006 / Dysfunctional tear syndrome:a Delphi approach to treatment recommendations / Cornea 25 : 900 ~ 907
Cuevas M / 2012 / Correlations among symptoms, signs, and clinical tests in evaporative-type dry eye disease caused by Meibomian gland dysfunction (MGD) / Curr Eye Res 37 : 8
De Paiva CS / 2006 / Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline / Invest Ophthalmol Vis Sci 47 : 284
De Paiva CS / 2006 / Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye /
Behrens A / 2006 / Dysfunctional tear syndrome:a Delphi approach to treatment recommendations / Cornea 25 : 900 ~ 907
Cuevas M / 2012 / Correlations among symptoms, signs, and clinical tests in evaporative-type dry eye disease caused by Meibomian gland dysfunction (MGD) / Curr Eye Res 37 : 8
De Paiva CS / 2006 / Apical corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline / Invest Ophthalmol Vis Sci 47 : 284
De Paiva CS / 2006 / Corticosteroid and doxycycline suppress MMP-9 and inflammatory cytokine expression, MAPK activation in the corneal epithelium in experimental dry eye /
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