지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 323 - 329 (7page)
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Purpose: To evaluate the relationship between the structural damage as assessed by time-domain optical coherencetomography (OCT) and functional changes in glaucoma.
Methods: In total, 190 patients with normal tension glaucoma or primary open angle glaucoma were included inthis study. The thickness of retinal nerve fiber layer (RNFL) around the optic disc and the area of RNFL defectwere determined using OCT scans. The relationships between the RNFL thickness or area of the defect andvisual field (VF) indices were assessed using the Lowess function, regression analysis and partial Spearmancorrelation. The differences between these associations depending on the stage of VF damage were furtheranalyzed. Age, optic disc size, refraction, central corneal thickness and the presence of systemic diseasewere corrected for in order to exclude confounding factors.
Results: A logarithmic scale of RNFL thickness showed a negative linear relationship with VF indices. The areaof the RNFL defect showed a weak correlation with the pattern of standard deviation, whereas the remnantRNFL thickness was moderately correlated with the pattern of standard deviation (partial Spearman correlationcoefficient, 0.39, -0.47, respectively; p < 0.0001). Many outliers were detected in the Lowess-plotted graphs.
Multiplication of the area and the inverted RNFL thickness showed a moderately correlated logarithmic relationshipwith the VF indices (partial Spearman correlation coefficient, 0.46; 95% confidence interval, 0.34 to 0.57; p< 0.0001). In the severe stage of VF damage, correlation between the area of the RNFL defect and mean deviationwas significantly greater than in other stages (partial Spearman correlation coefficient, -0.66; p = 0.02).
Conclusions: The thickness of the RNFL had a negative logarithmic correlation with the VF indices and wasmore relevant to the VF indices than the area of the RNFL defect, as measured by OCT.
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참고문헌 (16)
참고문헌 신청
Bellezza AJ / 2003 / Deformation of the lamina cribrosa and anterior scleral canal wall in early experimental glaucoma / Invest Ophthalmol Vis Sci 44 : 623 ~ 637
Chauhan BC / 2000 / Technique for detecting serial topographic changes in the optic disc and peripapillary retina using scanning laser tomography / Invest Ophthalmol Vis Sci
Cioffi GA / 2000 / Structural-functional relationships of the optic nerve in glaucoma / J Glaucoma 9 : 3 ~ 4
Garway-Heath DF / 2002 / Relationship between electrophysiological, psychophysical, and anatomical measurements in glaucoma / Invest Ophthalmol Vis Sci 43 : 2213 ~ 2220
Gramer E / 1986 / Site and depth of glaucomatous visual field defects in relation to the size of the neuroretinal edge zone of the optic disk in glaucoma without hypertensio
Chauhan BC / 2000 / Technique for detecting serial topographic changes in the optic disc and peripapillary retina using scanning laser tomography / Invest Ophthalmol Vis Sci
Cioffi GA / 2000 / Structural-functional relationships of the optic nerve in glaucoma / J Glaucoma 9 : 3 ~ 4
Garway-Heath DF / 2002 / Relationship between electrophysiological, psychophysical, and anatomical measurements in glaucoma / Invest Ophthalmol Vis Sci 43 : 2213 ~ 2220
Gramer E / 1986 / Site and depth of glaucomatous visual field defects in relation to the size of the neuroretinal edge zone of the optic disk in glaucoma without hypertensio
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