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Purpose: Since few reports had been published on the prevalence of toxocariasis in ankylosing spondylitis (AS)patients with acute non-granulomatous anterior uveitis (ANGAU), the aim of this work was to determine thepresence of antibodies against Toxocara canis in AS patients with ANGAU. Methods: Thirty-six patients (14 female and 22 male) with AS were enrolled in the study. The history of ANGAUwas accepted only if diagnosed by an ophthalmologist. The detection of IgG antibodies to T. canis was determinedby enzyme-linked immunosorbent assay. In addition, antibodies to Ascaris lumbricoides were alsotested to verify non-specific reactions. Results: The prevalence of ANGAU in the AS patients was 58% (21 / 36), and 38% (8 / 21) of the patients withANGAU were positive for antibodies to Toxocara, while 7% (1 / 15) of AS patients without ANGAU were positivefor T. canis (p = 0.038, two tails; mid-p exact). No antibodies were detected to A. lumbricoides antigens inthe serum samples of patients with AS. Conclusions: These data suggest that the seroprevalence of antibodies to T. canis is high in Mexican patientswith AS-associated uveitis, suggesting a chronic asymptomatic toxocariosis, which could be associated withthe pathogenesis of ANGAU; however, further larger-scale studies are needed to confirm this observation.

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