지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 137 - 141 (5page)
이용수
초록· 키워드
오류제보하기
Purpose: To compare the efficacies and safeties of Meditoxin® (Medy-Tox, Korea) and Botox® in the treatment of essential blepharospasm.
Methods: We performed a double-blind, randomized, comparative trial comparing Meditoxin® and Botox® for treatment of blepharospasm in 60 patients from the intention-to-treat (ITT) population and 52 patients from the per-protocol (PP) population. We analyzed the improvements in severity of spasm (SS) at four weeks post-injection as a primary efficacy outcome. Changes in eyelid closing force (CF) and functional visual status (FVS) after injection were analyzed for secondary efficacy outcomes, and adverse effects were demonstrated for the safety evaluation.
Results: Improvement in SS was noted in 90.3% of the Meditoxin® group and 86.2% of the Botox® group. There were no significant differences between treatment groups in the changes of CF and FVS post-injection (p>0.05). Since the lower limit of the 95% confidence interval (-1.76% for ITT, -1.64% for PP) was over the -15% threshold, we determined that Meditoxin® was not inferior to Botox® in either the ITT or PP populations. Adverse effects developed in 16.1% of the Meditoxin® group and 27.6% of the Botox® group, but no serious adverse events were found in either group.
Conclusions: Meditoxin® and Botox® were comparable in efficacy and safety in the treatment of essential blepharospasm.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Cakmur R / 2002 / Comparison of preseptal and pretarsal injections of botulinum toxin in the treatment of blepharospasm and hemifacial spasm / J Neurol 249 : 64 ~ 68
Cote TR / 2005 / Botulinum toxin type A injections: adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic cases / J Am Acad Dermatol 53
Elston JS / 1987 / Long-term results of treatment of idiopathic blepharospasm with botulinum toxin injections / Br J Ophthalmol 71 : 664 ~ 668
Greene P / 1994 / Development of resistance to botulinum toxin type A in patients with torticollis / Mov Disord 9 : 213 ~ 217
Hatheway CH / 1984 / Antitoxin levels in botulism patients treated with trivalent equine botulism antitoxin to toxin types A, B, and E / J Infect Dis 150 : 407 ~ 412
Cote TR / 2005 / Botulinum toxin type A injections: adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic cases / J Am Acad Dermatol 53
Elston JS / 1987 / Long-term results of treatment of idiopathic blepharospasm with botulinum toxin injections / Br J Ophthalmol 71 : 664 ~ 668
Greene P / 1994 / Development of resistance to botulinum toxin type A in patients with torticollis / Mov Disord 9 : 213 ~ 217
Hatheway CH / 1984 / Antitoxin levels in botulism patients treated with trivalent equine botulism antitoxin to toxin types A, B, and E / J Infect Dis 150 : 407 ~ 412
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