지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 611 - 619 (9page)
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초록· 키워드
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Imaging mass spectrometry (IMS) is currently receiving large attention from the mass spectrometric community, although its use is not yet well known in the clinic. As matrix-assisted laser desorption/ionization time-of-flight (MALDI)-IMS can show the biomolecular changes in cells as well as tissues, it can be an ideal tool for biomedical diagnostics as well as the molecular diagnosis of clinical specimens, especially aimed at the prompt detection of premalignant lesions much earlier before overt mass formation, or for obtaining histologic clues from endoscopic biopsy. Besides its use for pathologic diagnosis, MALDI-IMS is also a powerful tool for the detection and localization of drugs, proteins, and lipids in tissue. Measurement of parameters that define and control the implications, challenges, and opportunities associated with the application of IMS to biomedical tissue studies might be feasible through a deep understanding of mass spectrometry. In this focused review series, new insights into the molecular processes relevant to IMS as well as other field applications are introduced.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Alexandrov T. / 2012 / MALDI imaging mass spectrometry: statistical data analysis and current computational challenges / BMC Bioinformatics 13 (Suppl 16) : S11 ~
Andersson M / 2008 / Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction / Nat Methods 5 : 101 ~ 108
Apweiler R / 2009 / Approaching clinical proteomics: current state and future fields of application in cellular proteomics / Cytometry A 75 : 816 ~ 832
Azad NS / 2006 / Proteomics in clinical trials and practice: present uses and future promise / Mol Cell Proteomics 5 : 1819 ~ 1829
Bichsel VE / 2001 / Cancer proteomics: from biomarker discovery to signal pathway profiling / Cancer J 7 : 69 ~ 78
Andersson M / 2008 / Imaging mass spectrometry of proteins and peptides: 3D volume reconstruction / Nat Methods 5 : 101 ~ 108
Apweiler R / 2009 / Approaching clinical proteomics: current state and future fields of application in cellular proteomics / Cytometry A 75 : 816 ~ 832
Azad NS / 2006 / Proteomics in clinical trials and practice: present uses and future promise / Mol Cell Proteomics 5 : 1819 ~ 1829
Bichsel VE / 2001 / Cancer proteomics: from biomarker discovery to signal pathway profiling / Cancer J 7 : 69 ~ 78
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