지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 103 - 107 (5page)
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초록· 키워드
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Colorectal cancer is rare in teenagers, especially without known risk factors. Colon cancer in young age is more likely to be diagnosed at advanced-stage, to present unfavorable tumor histology such as mucinous carcinoma, and poor outcome. We report a case of sporadic mucinous adenocarcinoma of the colon in a 19-year-old male patient without any risk factors. He complained of severe left abdominal pain that developed 1 month ago. He had a distended abdomen with severe tenderness on the left lower quadrant. A distal descending colon mass causing mechanical obstruction was observed on abdominal computed tomography. Emergency colonoscopy showed a large, fungating mass obstructing the lumen at 40 cm from the anal verge. Biopsy of the colonic mass suggested a mucinous adenocarcinoma. After decompression by colonic stent, the patient was transferred to the general surgery department for left hemicolectomy. The lesion was confirmed to be a mucinous adenocarcinoma (7.0×4.5 cm). For hereditary nonpolyposis colorectal cancer evaluation, immunohistochemical staining for MLH1 and MSH2 was normal. Reverse transcription polymerase chain reaction analysis did not detect microinstability in any of the markers tested. The patient had no familial history of cancer. Mucinous adenocarcinoma has high frequencies of poor differentiation, advanced tumor stage, loss of mismatch repair gene expression, and increased MUC2 expression. A mucinous histology is considerably more frequent in children and adolescent than in adults. Adequate invasive study is also necessary for young age patients.
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참고문헌 (11)
참고문헌 신청
Brassett C / 1996 / Microsatellite instability in early onset and familial colorectal cancer / J Med Genet 33 : 981 ~ 985
Chiang JM / 2010 / Mucinous adenocarcinoma showing different clinicopathological and molecular characteristics in relation to different colorectal cancer subgroups / Int J Co
Dozois EJ / 2008 / Young-onset colorectal cancer in patients with no known genetic predisposition: can we increase early recognition and improve outcome? / Medicine 87 : 259
Du W / 2004 / Incidence and survival of mucinous adenocarcinoma of the colorectum: a population-based study from an Asian country / Dis Colon Rectum 47 : 78 ~ 85
Endreseth BH / 2006 / Rectal cancer in the young patient / Dis Colon Rectum 49 : 993 ~ 1001
Chiang JM / 2010 / Mucinous adenocarcinoma showing different clinicopathological and molecular characteristics in relation to different colorectal cancer subgroups / Int J Co
Dozois EJ / 2008 / Young-onset colorectal cancer in patients with no known genetic predisposition: can we increase early recognition and improve outcome? / Medicine 87 : 259
Du W / 2004 / Incidence and survival of mucinous adenocarcinoma of the colorectum: a population-based study from an Asian country / Dis Colon Rectum 47 : 78 ~ 85
Endreseth BH / 2006 / Rectal cancer in the young patient / Dis Colon Rectum 49 : 993 ~ 1001
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