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논문 기본 정보

자료유형
학술저널
저자정보
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대한산부인과학회 Obstetrics & Gynecology Science Obstetrics & Gynecology Science 제57권 제4호
발행연도
2014.1
수록면
281 - 290 (10page)

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ObjectiveIn this study, we evaluated the expression of FAS-associated factor 1 (FAF1) and heat shock protein 70 (HSP70) in normal ovary and ovarian cancer, and also analyzed the correlation between FAF1 and HSP70 in ovarian cancer. MethodsThe patient group consisted of 29 unrelated Korean women diagnosed as ovarian cancers and control samples were obtained from 7 patients who underwent oophorectomy for benign disease of uterus, and normal ovary was confirmed histologically from biopsy. We examined FAF1 and HSP70 expression by western blot analysis and immunohistochemical staining in normal ovary and ovarian cancer. Furthermore, we examined a correlation between FAF1 and HSP70 in ovarian cancer. ResultsThe expression of FAF1 was lower in ovarian cancer than that in normal ovary (P=0.02), and the expression of HSP70 was increased in ovarian cancer in comparison to that in normal ovary (P=0.03). The expression of FAF1 was decreased in advanced stages (stage III or stage IV) as compared with early stages (stage I or stage II) (P=0.01). The expression of HSP70 was not significantly related with ovarian cancer histology (P=0.10), but the expression of HSP70 was most increased with papillary serous carcinomas and undifferentiated ovarian cancer. The expression of FAF1 was inversely correlated with the expression of HSP70 in ovarian cancer (Spearman correlation coefficience=-0.47). ConclusionWe concluded that the expression of FAF1 or HSP70 each seems to have a meaning as a biomarker for early detection of ovarian cancer. The expressions of FAF1 and HSP70 seem to be more valuable in predicting ovarian cancer when used together because of their inverse correlation. This is the first study about the expression of FAF1 in ovarian cancer and the correlation between FAF1 and HSP70 expression in ovarian cancer.
#FAS-associated factor 1 #HSP70 heat-shock proteins #Ovarian neoplasms

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참고문헌 (25)

참고문헌 신청
American Cancer Society / 2010 / Cancer facts & figures / American Cancer Society google schola Anderson GL / 2010 / Ovarian cancer biomarker screening:still too early to tell / Womens Health (Lond Engl) 6 : 487 ~ 490 google schola Asea A / 2000 / HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine / Nat Med 6 : 435 ~ 442 google schola Bea S / 2009 / Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome prof google schola Berek JS / 1995 / Ovarian cancer screening. The use of serial complementary tumor markers to improve sensitivity and specificity for early detection / Cancer 76 (10 Suppl) : google schola

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