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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 405 - 420 (16page)
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초록· 키워드
오류제보하기
Preterm birth (PTB) is one of the most common complications during pregnancy and it primarily accounts for neonatal mortality and numerous morbidities including long-term sequelae including cerebral palsy and developmental disability. The most effective treatment of PTB is prediction and prevention of its risks. Risk factors of PTB include history of PTB, short cervical length (CL), multiple pregnancies, ethnicity, smoking, uterine anomaly and history of curettage or cervical conization. Among these risk factors, history of PTB, and short CL are the most important predictive factors. Progesterone supplement therapy is one of the few proven effective methods to prevent PTB in women with history of spontaneous PTB and in women with short CL. There are 2 types of progesterone therapy currently used for prevention of PTB: weekly intramuscular injection of 17-alpha hydroxyprogesterone caproate and daily administration of natural micronized progesterone vaginal gel, vaginal suppository, or oral capsule. However, the efficacy of progesterone therapy to prevent PTB may vary depending on the administration route, form, dose of progesterone and indications for the treatment. This review aims to summarize the efficacy and safety of progesterone supplement therapy on prevention of PTB according to different indication, type, route, and dose of progesterone, based on the results of recent randomized trials and meta-analysis.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Blencowe H / 2012 / National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries:a systematic analys
Cicinelli E / 2000 / Mechanisms of uterine specificity of vaginal progesterone / Hum Reprod 15 (1) : 159 ~ 165
Committee on Practice Bulletins?Obstetrics, The American College of Obstetricians and Gynecologists / 2012 / Practice bulletin no. 130: prediction and prevention of preterm
Facchinetti F / 2007 / Cervical length changes during preterm cervical ripening:effects of 17-alpha-hydroxyprogesterone caproate / Am J Obstet Gynecol 196 : 453.e1-4 ~
Harrison MS / 2016 / Global burden of prematurity / Semin Fetal Neonatal Med 21 : 74 ~ 79
Cicinelli E / 2000 / Mechanisms of uterine specificity of vaginal progesterone / Hum Reprod 15 (1) : 159 ~ 165
Committee on Practice Bulletins?Obstetrics, The American College of Obstetricians and Gynecologists / 2012 / Practice bulletin no. 130: prediction and prevention of preterm
Facchinetti F / 2007 / Cervical length changes during preterm cervical ripening:effects of 17-alpha-hydroxyprogesterone caproate / Am J Obstet Gynecol 196 : 453.e1-4 ~
Harrison MS / 2016 / Global burden of prematurity / Semin Fetal Neonatal Med 21 : 74 ~ 79
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