지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 37 - 43 (7page)
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초록· 키워드
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ObjectiveThis study evaluated the effect of the specific human papillomavirus (HPV) genotypes on severity and prognosis in cervical intraepithelial neoplasia (CIN) patients.
MethodsThe medical records of 446 patients treated with loop electrosurgical excision procedure (LEEP) were reviewed. The severity of CIN was categorized as CIN1/CIN2 versus CIN3+ including CIN3 and carcinoma in situ (CIS). HPV genotypes were categorized as 1) low risk, 2) intermediate risk, 3) high risk/HPV 16, 4) high risk/HPV 18, and 5) unclassified. Progression was defined as abnormal cytology, including atypical squamous cells, low-grade squamous intraepithelial lesion and high-grade squamous intraepithelial lesion. The margin status and progression free survival (PFS) by HPV genotypes were analyzed in 355 women with three months or more of post-treatment records.
ResultsCIN3+ was the most common CIN type (67.7%), and high risk/HPV 16 (26.9%) was the most common genotype. Intermediate risk (P < 0.01), high risk/HPV 16 (P < 0.01) and high risk/HPV 18 (P < 0.01) were significantly more common in women with CIN3+ than CIN1/CIN2. Patients with high risk/HPV 18 showed the highest rate of positive margins (P < 0.01). The margin status proved to be the only statistically significant factor affecting PFS.
ConclusionThe proportion of positive margins was significantly different by HPV genotypes and highest in high risk/HPV 18 group. CIN patients with high risk/HPV 18 need to be more carefully tracked than patients with the other HPV genotypes.
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참고문헌 (22)
참고문헌 신청
ASCUS-LSIL Traige Study (ALTS) Group / 2003 / Results of a randomized trial on the management of cytology interpretations of atypical squamous cells of undetermined signific
An HJ / 2003 / Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method / Cancer
Burger RA / 1996 / Human papillomavirus type 18:association with poor prognosis in early stage cervical cancer / J Natl Cancer Inst 88 : 1361 ~ 1368
Castle PE / 2007 / The relationship of community biopsy-diagnosed cervical intraepithelial neoplasia grade 2 to the quality control pathology-reviewed diagnoses: an ALTS repo
Chang DY / 1996 / Prediction of residual neoplasia based on histopathology and margin status of conization specimens / Gynecol Oncol 63 : 53 ~ 56
An HJ / 2003 / Correlation of cervical carcinoma and precancerous lesions with human papillomavirus (HPV) genotypes detected with the HPV DNA chip microarray method / Cancer
Burger RA / 1996 / Human papillomavirus type 18:association with poor prognosis in early stage cervical cancer / J Natl Cancer Inst 88 : 1361 ~ 1368
Castle PE / 2007 / The relationship of community biopsy-diagnosed cervical intraepithelial neoplasia grade 2 to the quality control pathology-reviewed diagnoses: an ALTS repo
Chang DY / 1996 / Prediction of residual neoplasia based on histopathology and margin status of conization specimens / Gynecol Oncol 63 : 53 ~ 56
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