지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 89 - 97 (9page)
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초록· 키워드
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Objective To assess the effi ciency of anti-Müllerian hormone (AMH), follicle-stimulating hormone (FSH), estradiol, antral follicle count (AFC),endometrial thickness (EMT), and clinical fi ndings as predictive markers of menopause in late reproductive-aged Korean women.
Methods A cohort of 104 women, aged 45 to 55 years in their menopausal transition were selected. The participants were assessed twice (T1 and T2) at a mean interval of 13.1 months. At each time, their menstrual history was determined; pelvic ultrasonography was performed to evaluate AFC and EMT; blood sampling was done. A logistic regression analysis using the SPSS ver. 17.0 was performed, with the outcome measure of menopause at T2.
Results Of the 104 participants, 33 were postmenopausal based on their menstrual history at T2. Compared with women who stayed in the menopausal transition period, those who became postmenopausal at T2 differed signifi cantly with regard to the following factors at T1: FSH, estradiol, EMT, AFC, days from the last menstrual cycle, and interval between the last 2 cycles. However, AMH levels were not different between the groups. Of all the parameters, a longer number of days from the last menstrual cycle and time interval between the last 2 cycles were signifi cantly associated with the occurrence of menopause.
Conclusion This study indicates that AMH is not a predictive marker of menopause in late reproductive-aged women over a relatively short timeframe (range, 0.5 to 2.5 years). Time since the last menstruation at T1 was a better predictor of menopause.
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참고문헌 (22)
참고문헌 신청
Broer SL / 2011 / Themmen AP, et al. Anti-mullerian hormone predicts menopause: a long-term follow-up study in normoovulatory women / J Clin Endocrinol Metab 96 : 2532 ~ 253
Burger HG / 2007 / A review of hormonal changes during the menopausal transition: focus on fi ndings from the Melbourne Women’s Midlife Health Project / Hum Reprod Update 13
Fanchin R / 2007 / Anti-Mullerian hormone concentrations in the follicular fl uid of the preovulatory follicle are predictive of the implantation potential of the ensuing em
Flaws JA / 2000 / Ovarian volume and menopausal status / Menopause 7 : 53 ~ 61
Flaws JA / 2001 / Ovarian volume and antral follicle counts as indicators of menopausal status / Menopause 8 : 175 ~ 180
Burger HG / 2007 / A review of hormonal changes during the menopausal transition: focus on fi ndings from the Melbourne Women’s Midlife Health Project / Hum Reprod Update 13
Fanchin R / 2007 / Anti-Mullerian hormone concentrations in the follicular fl uid of the preovulatory follicle are predictive of the implantation potential of the ensuing em
Flaws JA / 2000 / Ovarian volume and menopausal status / Menopause 7 : 53 ~ 61
Flaws JA / 2001 / Ovarian volume and antral follicle counts as indicators of menopausal status / Menopause 8 : 175 ~ 180
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