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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 649 - 654 (6page)
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초록· 키워드
오류제보하기
ObjectiveIsotretinoin is a notorious teratogen otherwise used for the treatment of acne vulgaris. Some countries, includingthose in North America and the European Union, implemented the pregnancy prevention program (PPP); however,no PPP has yet been established in South Korea. So the aim of this study was to evaluate the rate of pregnant womenexposed to isotretinoin among the callers of the Korean Mother Safe Counseling Center. MethodsThis is a prospective cohort study. We evaluated the demographic characteristics, obstetric history, and isotretinoinexposure of pregnant women based on the mother safe registry from April 2010 to July 2016. ResultsAmong 22,374 callers, 650 (2.9%) pregnant women were exposed to isotretinoin. The mean age was 29.0±4.4 yearsin the isotretinoin-exposed group and 32.0±4.2 years in the unexposed group (P<0.001). Moreover, the incidence ofpregnancies within 30 days after isotretinoin discontinuation or during isotretinoin intake was 78.9% (513/650). Themedian duration of isotretinoin exposure was 18 (1–4,231) days. Furthermore, from 2011 to 2015, the incidence ofisotretinoin exposure was 2.9±1.2 pregnancies per 10,000 births in South Korea. ConclusionApproximately 80% of pregnant women are exposed to isotretinoin within the recommended 30 days ofcontraception or during pregnancy. Therefore, the PPP has to be established in South Korea.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Layton A / 2009 / The use of isotretinoin in acne / Dermatoendocrinol 1:162~169
Korea Pharmaceutical Information Center / Isotretinoin information
Azoulay L / 2006 / Patterns and utilization of isotretinoin for acne from 1984 to 2003: is there need for concern? / Eur J Clin Pharmacol 62:667~674
Honein MA / 2001 / Continued occurrence of Accutane-exposed pregnancies / Teratology 64:142~147
Lammer EJ / 1985 / Retinoic acid embryopathy / N Engl J Med 313:837~841
Korea Pharmaceutical Information Center / Isotretinoin information
Azoulay L / 2006 / Patterns and utilization of isotretinoin for acne from 1984 to 2003: is there need for concern? / Eur J Clin Pharmacol 62:667~674
Honein MA / 2001 / Continued occurrence of Accutane-exposed pregnancies / Teratology 64:142~147
Lammer EJ / 1985 / Retinoic acid embryopathy / N Engl J Med 313:837~841
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