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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 69 - 73 (5page)
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초록· 키워드
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Objective: The aim of this study was to evaluate the effect of short-term use of selective progesterone receptor modulator (SPRM) or gonadotropin-releasing hormone (GnRH) agonist on uterine fibroid shrinkage among Korean women.
Methods: This retrospective study involved 101 women with symptomatic uterine fibroids who received ulipristal acetate (SPRM, n=51) and leuprolide acetate (GnRH agonist, n=50) for 3 months between November 2013 and February 2015. The fibroid volume was measured both before and after treatment using ultrasonography, computed tomography, and magnetic resonance imaging. The outcomes were compared between the SPRM and GnRH agonist groups.
Results: The median rate of fibroid volume reduction after SPRM treatment was 12.4% (IQR -14.5% to 40.5%) which was significantly lower than the reduction rate observed after GnRH agonist treatment (median 34.9%, IQR 14.7% to 48.6%, P=0.004). 19 of 51 (37.3%) patients with SPRM treatment did not show any response of volume shrinkage, while 7 of 50 (14.0%) women with GnRH agonist showed no response (P=0.007).
Conclusion: Short-term SPRM treatment yields lower volume reduction than GnRH agonist treatment in Korean women with symptomatic fibroids. Further large-scale randomized trials are needed to confirm our findings.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Blithe DL / 2003 / Development of the selective progesterone receptor modulator CDB-2914 for clinical indications / Steroids 68 : 1013 ~ 1017
Buttram VC Jr / 1981 / Uterine leiomyomata: etiology, symptomatology, and management / Fertil Steril 36 : 433 ~ 445
Campo S / 1999 / Laparoscopic myomectomy in premenopausal women with and without preoperative treatment using gonadotrophin-releasing hormone analogues / Hum Reprod 14 : 44 ~
Chwalisz K / 2005 / Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis / Endocr Rev 26 : 423 ~ 438
Croxtall JD / 2012 / Ulipristal acetate: in uterine fibroids / Drugs 72 : 1075 ~ 1085
Buttram VC Jr / 1981 / Uterine leiomyomata: etiology, symptomatology, and management / Fertil Steril 36 : 433 ~ 445
Campo S / 1999 / Laparoscopic myomectomy in premenopausal women with and without preoperative treatment using gonadotrophin-releasing hormone analogues / Hum Reprod 14 : 44 ~
Chwalisz K / 2005 / Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis / Endocr Rev 26 : 423 ~ 438
Croxtall JD / 2012 / Ulipristal acetate: in uterine fibroids / Drugs 72 : 1075 ~ 1085
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