지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 29 - 35 (7page)
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초록· 키워드
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Objective The aim of this study was to evaluate the prognostic value of serum CA-125 in advanced epithelial ovarian cancer with complete remission after primary adjuvant chemotherapy.
Methods We reviewed the records of 120 patients with advanced epithelial ovarian cancer who underwent primary surgery followed by adjuvant therapy at our institution between January 1998 and December 2005.
Results The median progression free survival was 21.6 months and 12.5 months in patients with nadir CA-125 levels ≤10 U/mL and 10 to 35 U/mL, respectively. Median overall survival in the same respective order was 130.2 months and 35.3 months. The level of serum CA-125 after the first cycle of adjuvant chemotherapy was most significantly higher in the recurrent group compared with the non-recurrent group. The optimal cut point of CA-125 on the receiver operating characteristic curve was 35 U/mL. Median progression free survival was 64.6 months and 12.8 months in patients with nadir CA-125 levels ≤35 U/mL and >35 U/mL, respectively, after first cycle of adjuvant chemotherapy.
Conclusion Serum CA-125 level after the first cycle of adjuvant chemotherapy is a strong independent prognostic factor for advanced epithelial ovarian cancer with complete response.
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참고문헌 (18)
참고문헌 신청
Benedet JL / 2000 / FIGO staging classifications and clinical practice guidelines in the management of gynecologic cancers / Int J Gynaecol Obstet 70 : 209 ~ 262
Cooper BC / 2002 / Preoperative CA 125 levels: an independent prognostic factor for epithelial ovarian cancer / Obstet Gynecol 100 : 59 ~ 64
Crawford SM / 2005 / Does the nadir CA125 concentration predict a long-term outcome after chemotherapy for carcinoma of the ovary? / Ann Oncol 16 : 47 ~ 50
Engel J / 2002 / Moderate progress for ovarian cancer in the last 20 years: prolongation of survival, but no improvement in the cure rate / Eur J Cancer 38 : 2435 ~ 2445
Ivanov S / 2003 / Epithelial ovarian cancer: preoperative assessment of Ca 125 levels as an independent prognostic factor / Akush Ginekol (Sofiia) 42 : 16 ~ 19
Cooper BC / 2002 / Preoperative CA 125 levels: an independent prognostic factor for epithelial ovarian cancer / Obstet Gynecol 100 : 59 ~ 64
Crawford SM / 2005 / Does the nadir CA125 concentration predict a long-term outcome after chemotherapy for carcinoma of the ovary? / Ann Oncol 16 : 47 ~ 50
Engel J / 2002 / Moderate progress for ovarian cancer in the last 20 years: prolongation of survival, but no improvement in the cure rate / Eur J Cancer 38 : 2435 ~ 2445
Ivanov S / 2003 / Epithelial ovarian cancer: preoperative assessment of Ca 125 levels as an independent prognostic factor / Akush Ginekol (Sofiia) 42 : 16 ~ 19
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