지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 513 - 517 (5page)
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초록· 키워드
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ObjectiveThromogenic gene mutations has been thought to be associated with recurrent pregnancy loss in women in Turkey. The aim of this study was to investigate the prevalence of thromogenic gene mutations such as factor V Leiden (FVL, G1691T), prothrombin (G20210A), and the methylene tetrahydrofolate reductase (MTHFR, C677T) mutation in women with recurrent pregnancy loss.
MethodsThis descriptive study was carried out in the Department of Obstetrics and Gynaecology, Harran University School of Medicine, and included a total of 1,507 women with histories of recurrent pregnancy loss between January 2010 and June 2013. The mutations were assessed by using the polymerase chain reaction.
ResultsThe homozygous mutation frequencies of FVL, prothrombin, and MTHFR were found to be 3 (0.20%), 0 and 125 (8.29%), and the heterozygous mutation frequencies were 83 (5.51%), 61 (4.05%), and 612 (40.61%), respectively. Among the 86 FVL mutation patients, 38 also had accompanying prothrombin and MTHFR mutations.
ConclusionSince the homozygous forms of the FVL—prothrombin gene mutations have low incidences and MTHFR mutation is similar to a healthy population, preconceptional thromogenic gene mutations screening seems to be controversial.
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참고문헌 (24)
참고문헌 신청
Akar N / 2009 / Factor V 1691 G-A mutation distribution in a healthy Turkish population / Turk J Haematol 26 : 9 ~ 11
Altintas A / 2007 / Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey / Ann Hematol 86 : 727 ~ 7
Ayadurai T / 2009 / Thrombophilia investigation in Malaysian women with recurrent pregnancy loss / J Obstet Gynaecol Res 35 : 1061 ~ 1068
Ayyildiz O / 2004 / Prothrombin G20210A gene mutation with LightCycler polymerase chain reaction in venous thrombosis and healthy population in the southeast of Turkey / Hea
Behjati R / 2006 / Thrombophilic mutations in Iranian patients with infertility and recurrent spontaneous abortion / Ann Hematol 85 : 268 ~ 271
Altintas A / 2007 / Factor V Leiden and G20210A prothrombin mutations in patients with recurrent pregnancy loss: data from the southeast of Turkey / Ann Hematol 86 : 727 ~ 7
Ayadurai T / 2009 / Thrombophilia investigation in Malaysian women with recurrent pregnancy loss / J Obstet Gynaecol Res 35 : 1061 ~ 1068
Ayyildiz O / 2004 / Prothrombin G20210A gene mutation with LightCycler polymerase chain reaction in venous thrombosis and healthy population in the southeast of Turkey / Hea
Behjati R / 2006 / Thrombophilic mutations in Iranian patients with infertility and recurrent spontaneous abortion / Ann Hematol 85 : 268 ~ 271
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