지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 870 - 873 (4page)
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초록· 키워드
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Here, we present a case of endometrial cancer six years after colon cancer in a Lynch syndrome patient at one institution. A 36-year-old Asian woman underwent surgery for colon cancer and six years later she underwent surgery for endometrial cancer.
Based on a family history of cancer, she underwent genetic testing, including gene sequencing, after she contracted the colon cancer. A microsatellite instability test was performed and showed an unstable fi nal result. Gene sequencing (MSH2 ) revealed a mutation at c.2649 T>G (p.1883M). However, her follow-up was not normal. In the second operation, immunohistochemistry showed that her endometrium stained negatively for MSH2 , consistent with the previous test. As far as we know, this is a fi rst case of metachronous cancer sin Korea regarding Lynch syndrome in single institution. It is important for enterocolonists and gynecological oncologists to screen effectively to reduce the mortality and costs associated with these genetic malignancies.
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참고문헌 (11)
참고문헌 신청
Fishel R / 1993 / The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer / Cell 75:1027~1038
Leach FS / 1993 / Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer / Cell 75:1215~1225
Umar A / 2004 / Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability / J Natl Cancer Inst 96:261~268
Burke W / 1997 / Recommendations for follow-up care of individuals with an inherited predisposition to cancer. I. Hereditary nonpolyposis colon cancer. Cancer Genetics Studies Consortium / JAMA 277:915~919
Järvinen HJ / 1995 / Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer / Gastroenterology 108:1405~1411
Leach FS / 1993 / Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer / Cell 75:1215~1225
Umar A / 2004 / Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability / J Natl Cancer Inst 96:261~268
Burke W / 1997 / Recommendations for follow-up care of individuals with an inherited predisposition to cancer. I. Hereditary nonpolyposis colon cancer. Cancer Genetics Studies Consortium / JAMA 277:915~919
Järvinen HJ / 1995 / Screening reduces colorectal cancer rate in families with hereditary nonpolyposis colorectal cancer / Gastroenterology 108:1405~1411
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