지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 180 - 182 (3page)
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초록· 키워드
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Wilson’s disease is a rare hereditary disorder of copper metabolism affecting 30 per million populations. Copper get deposited in liver, brain and kidney due to decreased hepato-cellular excretion and leading to diverse clinical manifestations. Patient may remain apparently asymptomatic or may present with fulminant liver disease or neuropsychiatric illness. Reproductive outcome in untreated Wilson’s disease is poor. Women remaining untreated either suffer from infertility or experience recurrent pregnancy losses. Invention of copper chelating agents and their usage in these women resulted in successful pregnancy outcome.
Penicillamine or zinc salts can be used as copper chelator in pregnancy with Wilson’s disease with equal effectiveness in respect to pregnancy outcome. We report a case of previously undiagnosed Wilson’s disease with three consecutive pregnancy losses who achieved a live birth after successfully treated with zinc salts. The several points regarding antenatal care, drug therapy and optimum time and mode of delivery for the woman with Wilson’s disease are discussed here.
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참고문헌 (5)
참고문헌 신청
Brewer GJ / 2000 / Treatment of Wilson’s disease with zinc. XVII: treatment during pregnancy / Hepatology 31 : 364 ~ 370
Kroll CA / 2006 / Retrospective determination of ceruloplasmin in newborn screening blood spots of patients with Wilson disease / Mol Genet Metab 89 : 134 ~ 138
Roberts EA / 2008 / Diagnosis and treatment of Wilson disease: an update. Hepatology / Hepatology 47 : 2089 ~ 2111
Scheinberg IH / 1975 / Pregnancy in penicillamine-treated patients with Wilson’s disease / N Engl J Med 293 : 1300 ~ 1302
Sinha S / 2004 / Successful pregnancies and abortions in symptomatic and asymptomatic Wilson’s disease / J Neurol Sci 217 : 37 ~ 40
Kroll CA / 2006 / Retrospective determination of ceruloplasmin in newborn screening blood spots of patients with Wilson disease / Mol Genet Metab 89 : 134 ~ 138
Roberts EA / 2008 / Diagnosis and treatment of Wilson disease: an update. Hepatology / Hepatology 47 : 2089 ~ 2111
Scheinberg IH / 1975 / Pregnancy in penicillamine-treated patients with Wilson’s disease / N Engl J Med 293 : 1300 ~ 1302
Sinha S / 2004 / Successful pregnancies and abortions in symptomatic and asymptomatic Wilson’s disease / J Neurol Sci 217 : 37 ~ 40
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