지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 58 - 66 (9page)
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Since the existence of cell-free fetal DNA (cff-DNA) in maternal circulation was discovered, it has been identified as a promising source of fetal genetic material in the development of reliable methods for non-invasive prenatal diagnosis (NIPD) of fetal trisomy 21 (T21). Currently, a prenatal diagnosis of fetal T21 is achieved through invasive techniques, such as chorionic villus sampling or amniocentesis. However, such invasive diagnostic tests are expensive, require expert technicians, and have a miscarriage risk approximately 1%. Therefore, NIPD using cff-DNA in the detection of fetal T21 is significant in prenatal care. Recently, the application of new techniques using single-molecular counting methods and the development of fetal-specific epigenetic markers has opened up new possibilities in the NIPD of fetal T21 using cff-DNA. These new technologies will facilitate safer, more sensitive and accurate prenatal tests in the near future. In this review, we investigate the recent methods for the NIPD of fetal T21 and discuss their implications in future clinical practice.
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참고문헌 (24)
참고문헌 신청
ACOG Committee on Practice Bulletins / 2007 / ACOG Practice Bulletin No. 77: screening for fetal chromosomal abnormalities / Obstet Gynecol 109 : 217 ~ 227
Alfirevic Z / 2003 / Amniocentesis and chorionic villus sampling for prenatal diagnosis / Cochrane Database Syst Rev (3) : CD003252 ~
American College of Obstetricians and Gynecologists / 2007 / ACOG Practice Bulletin No. 88, December 2007. Invasive prenatal testing for aneuploidy / Obstet Gynecol 110 : 145
Bianchi DW / 2002 / Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data. National Institute of Child Health and Development F
Cheung MC / 1996 / Prenatal diagnosis of sickle cell anaemia and thalassaemia by analysis of fetal cells in maternal blood / Nat Genet 14 : 264 ~ 268
Alfirevic Z / 2003 / Amniocentesis and chorionic villus sampling for prenatal diagnosis / Cochrane Database Syst Rev (3) : CD003252 ~
American College of Obstetricians and Gynecologists / 2007 / ACOG Practice Bulletin No. 88, December 2007. Invasive prenatal testing for aneuploidy / Obstet Gynecol 110 : 145
Bianchi DW / 2002 / Fetal gender and aneuploidy detection using fetal cells in maternal blood: analysis of NIFTY I data. National Institute of Child Health and Development F
Cheung MC / 1996 / Prenatal diagnosis of sickle cell anaemia and thalassaemia by analysis of fetal cells in maternal blood / Nat Genet 14 : 264 ~ 268
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