지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 470 - 476 (7page)
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초록· 키워드
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Introduction: The incidence of bisphosphonate-related osteonecrosis of the jaw (BRONJ) has increased gradually in patients who have undergone surgical treatment for osteomyelitis. In this study, a retrospective analysis of BRONJ patients was carried out using the data of osteomyelitis patients treated surgically.
Materials and Methods: Osteomyelitis patients, who underwent curettage, sequestrectomy, saucerization or decortications, and partial mandibulectomy at Seoul National University Dental Hospital from 2004 to 2010 were enrolled in this study. The patients were classified and categorized into two groups based on the surgical records and progress notes. One group comprised of patients with osteomyelitis and osteoporosis,and the other group included patients with osteomyelitis only. The epidemiological data of the BRONJ patients was analyzed to identify any trend in the incidence of BRONJ in osteomyelitis patients.
Results: Among 200 patients who underwent surgical intervention for osteomyelitis, 64 (32.0%) were identified as having osteoporosis as the underlying disease. In these 64 patients, more than 81.3% had been prescribed bisphosphonates. Females were far more affected by BRONJ than males. The incidence of BRONJ also increased with age. The posterior part of the mandible was affected more frequently by BRONJ.
Conclusion: Although the availability of potent antibiotics and increased oral hygiene care can reduce the overall incidence of osteomyelitis, BRONJ can increase the total incidence. To prevent BRONJ, it is recommended that an oral examination be performed before prescribing bisphosphonates.
Moreover, the patients should be educated about the potential risks of dental procedures that might be causal factors for BRONJ. Furthermore, patient swho take bisphosphonates for the treatment of osteoporosis should undergo periodic follow up oral examinations to prevent BRONJ.
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참고문헌 (20)
참고문헌 신청
Adamo V / 2008 / Current knowledge and future directions on bisphosphonaterelated osteonecrosis of the jaw in cancer patients / Expert Opin Pharmacother 9 : 1351 ~ 1361
Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons / 2007 / American Association of Oral and Ma
Allen MR / 2009 / Higher bone matrix density exists in only a subset of patients with bisphosphonate-related osteonecrosis of the jaw / J Oral Maxillofac Surg 67 : 1373 ~ 13
Carlson ER / 2009 / The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws / J Oral Maxillofac Surg 67 (5 Suppl) : 85 ~ 95
Hoefert S / 2011 / Relevance of a prolonged preoperative antibiotic regime in the treatment of bisphosphonate-related osteonecrosis of the jaw / J Oral Maxillofac Surg : 362
Advisory Task Force on Bisphosphonate-Related Ostenonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons / 2007 / American Association of Oral and Ma
Allen MR / 2009 / Higher bone matrix density exists in only a subset of patients with bisphosphonate-related osteonecrosis of the jaw / J Oral Maxillofac Surg 67 : 1373 ~ 13
Carlson ER / 2009 / The role of surgical resection in the management of bisphosphonate-related osteonecrosis of the jaws / J Oral Maxillofac Surg 67 (5 Suppl) : 85 ~ 95
Hoefert S / 2011 / Relevance of a prolonged preoperative antibiotic regime in the treatment of bisphosphonate-related osteonecrosis of the jaw / J Oral Maxillofac Surg : 362
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