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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 308 - 315 (8page)
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초록· 키워드
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Aim: The aim of this study was to investigate the mechanism of promoted skin wound healing in skin defects with primary cultured oral mucosal keratinocytes. Materials and methods: Thirty adult female nude mice weighing 20±2g were used for the experiment. Primary cultured and suspended oral mucosal keratinocytes, labeled with BrdU, were scattered onto 1.5㎝×1.5㎝ sized full thickness skin defects in the experimental group(N=15), and no grafts were placed the control group(N=15). They were sacrificed at 3 days, 1 week and 2 weeks after the treatment respectively. Histological examination of each wounds were performed to review the healing progress on measuring the length from the wound margin to regenerating epithelial front. The role of keratinocytes were assessed by double immunohistochemical staining with Anti-BrdU and Anti-cytokeratin AE1/3. Results: In the experimental group the wound was completely covered with regenerating epithelia in 2 weeks, but partially regenerated in the control group. The immunohistochemical studies unexpectedly reveal that most of regenerating epithelial cells were induced from marginal epithelium of the margin, not from the scattered keratinocytes.Conclusion: We could successfully confirm that graft of primary cultured oral mucosal keratinocytes promotes the regeneration of skin defects.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
/ / Connective tissue influences on patterns of epithelial architecture and keratinization in skin and oral mucosa of the adult mouse skin. Cell Tissue Res 1984 : 551 ~ 9
/ / Correlation of specific keratins with different types of epithelial differentiation : 361 ~ 72
/ / Detection of transforming growth factor alpha in normal : 670 ~ 5
/ / Epidermal cytokines and their roles in cutaneous wound healing. Br J Dermatol. 1991 : 513 ~ 8
/ / Growth and differentiation properties of normal and transformed human keratinocytes in organotypic culture. Jpn J Cancer Res. 1994 koh (y) : 238 ~ 44
/ / Correlation of specific keratins with different types of epithelial differentiation : 361 ~ 72
/ / Detection of transforming growth factor alpha in normal : 670 ~ 5
/ / Epidermal cytokines and their roles in cutaneous wound healing. Br J Dermatol. 1991 : 513 ~ 8
/ / Growth and differentiation properties of normal and transformed human keratinocytes in organotypic culture. Jpn J Cancer Res. 1994 koh (y) : 238 ~ 44
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