지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.1
- 수록면
- 240 - 245 (6page)
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초록· 키워드
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Angiokeratoma is a benign cutaneous lesion of the capillaries, presenting as dilated vessels in the upper part of the dermis. Although this disorder is classified into various types and has been occasionally reported in the skin of the scrotum or extremities, the involvement of the oral cavity mucosa has been rarely reported. The present study reports a case of angiokeratoma circumscriptum in the buccal mucosa. The expression of vascular endothelial growth factor (VEGF) and both of its receptors (VEGFR-1 and VEGFR-2) was demonstrated by immunohistochemistry in the endothelial cells lining the dilated vessels. The expression of VEGFR-2 was higher than that of VEGFR-1 in the endothelial cells in the lesion, indicating an increased rate of endothelial cell proliferation within the lesion. Interestingly, some of the endothelial cells co-expressed VEGF and its two receptors. These results suggest that endothelial cells in the pathologically dilated vessels possess VEGF autocrine growth activity involved in vasculogenesis and maintenance in angiokeratoma lesions. To our knowledge, this is the second report published on isolated oral angiokeratoma confined to the buccal mucosa and the first case report on angiokeratoma circumscriptum involving the buccal mucosa.
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참고문헌 (17)
참고문헌 신청
Bhargava P / 2001 / Angiokeratoma of tongue / Indian J Dermatol Venereol Leprol 67 : 270 ~
Erkal EY / 2013 / Solitary angiokeratoma of the tongue in an adult patient treated with intensity modulated radiation therapy / Am J Otolaryngol 34 : 582 ~ 585
Fabry J / 1915 / Uber einen fall von angiokeratoma circumscriptum am linken oberschenkel / Derm Z 22 : 1 ~ 4
Green JB / 2006 / Angiokeratoma circumscriptum of the dorsal tongue in a child / Int J Pediatr Otorhinolaryngol Extra 1 : 107 ~ 109
Kobayashi T / 1998 / A case of angiokeratoma circumscriptum: immunolocalization of matrix metalloproteinase (MMP)-9 / J Dermatol 25 : 391 ~ 394
Erkal EY / 2013 / Solitary angiokeratoma of the tongue in an adult patient treated with intensity modulated radiation therapy / Am J Otolaryngol 34 : 582 ~ 585
Fabry J / 1915 / Uber einen fall von angiokeratoma circumscriptum am linken oberschenkel / Derm Z 22 : 1 ~ 4
Green JB / 2006 / Angiokeratoma circumscriptum of the dorsal tongue in a child / Int J Pediatr Otorhinolaryngol Extra 1 : 107 ~ 109
Kobayashi T / 1998 / A case of angiokeratoma circumscriptum: immunolocalization of matrix metalloproteinase (MMP)-9 / J Dermatol 25 : 391 ~ 394
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