지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 121 - 126 (6page)
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초록· 키워드
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Aberrations on the short arm of chromosome 8 (8p) are frequently observed in several human cancers. In this study, 20 squamous cell carcinoma (SCC) specimens from the tongue were examined in order to evaluate the role of 8p in SCC of the tongue. Microsatellite analysis using 14 markers demonstrated two commonly deleted regions (CDRs) on 8p. Reverse transcription-polymerase chain reaction (RT-PCR) revealed frequent down-regulation of the FEZ1 gene, mapped to 8p22, and frequent over-expression of the cathepsin B gene, mapped to 8p-21-22. These results suggested that genetic aberrations are involved in the development of SCC of the tongue. However, no significant relationship was observed to be established between the genetic alterations and clinicopathological features. Thus, further investigation is necessary in order to clarify the clinical role of 8p in carcinoma of the tongue.
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참고문헌 (24)
참고문헌 신청
Cunningham C / 1994 / Deletion analysis of chromosome 8p in sporadic colorectal adenomas / Br J Cancer 70 : 18 ~ 20
Ishii H / 1999 / The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors / Proc Natl Acad Sci U S A 96 : 3928 ~ 3
Kawaki J / 2000 / Allelic loss in human intrahepatic cholangiocarcinoma: correlation between chromosome 8p22 and tumor progression / Int J Cancer 88 : 228 ~ 231
Kerangueven F / 1995 / Loss of heterozygosity and linkage analysis in breast carcinoma: indication for a putative third susceptibility gene on the short arm of chromosome 8 /
Knowles MA / 1993 / Deletion mapping of chromosome 8 in cancers of the urinary bladder using restriction fragment length polymorphisms and microsatellite polymorphisms / Onco
Ishii H / 1999 / The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors / Proc Natl Acad Sci U S A 96 : 3928 ~ 3
Kawaki J / 2000 / Allelic loss in human intrahepatic cholangiocarcinoma: correlation between chromosome 8p22 and tumor progression / Int J Cancer 88 : 228 ~ 231
Kerangueven F / 1995 / Loss of heterozygosity and linkage analysis in breast carcinoma: indication for a putative third susceptibility gene on the short arm of chromosome 8 /
Knowles MA / 1993 / Deletion mapping of chromosome 8 in cancers of the urinary bladder using restriction fragment length polymorphisms and microsatellite polymorphisms / Onco
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