지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 16 - 22 (7page)
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초록· 키워드
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Purpose: The purpose of this study was not only to evaluate the relative mRNA expression of interleukin-1β(IL-1β), cyclooxygenase2 (COX-2)and prostaglandin E2 (PGE2) by RT-PCR analysis but to observe pattern of edema by light microscopic and electron microscope after topical apply of hyaluronic acid in inflammation-guided mouse.
Material and methods: Mice of this study were devided into 4 groups: Control group (no inflammation guided), Positive control (inflammation guided + vaselin apply), Protopic group (inflammation guided + protopic apply), Hyaluronic group (inflammation guided + hyaluronic acid apply).
Results: Hyaluronic group showed less expressions of IL-1β, COX-2, PGE2 than those of positive control & protopic group. Hyaluronic group revealed a decreased inflammation than positive control & protopic group in Light Microscope.
Hyaluronic group appeared decreased edema of ear compare to positive control & protopic group in Elecron Microscope.
Conclusion: It was considered that hyaluronic acid has an antiinflammatory effect for intercepting the gene expression of cytokines related to inflammation.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Adams ME / 1995 / The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-
Altman RD / 1999 / A randomized clinical trial of intraarticular sodium hyaluronate in patients with osteoarthritis of the knee: a summary / Am J Orthop (Belle Mead NJ) 28 :
Caporossi A / 1995 / Healon GV versus Healon in demanding cataract surgery / J Cataract Refract Surg 21 : 710 ~ 713
Ghosh K / 2006 / Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing / Tissue Eng 12 : 601 ~ 61
Heldin P / 1989 / Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts / Biochem J 258 : 919 ~ 922
Altman RD / 1999 / A randomized clinical trial of intraarticular sodium hyaluronate in patients with osteoarthritis of the knee: a summary / Am J Orthop (Belle Mead NJ) 28 :
Caporossi A / 1995 / Healon GV versus Healon in demanding cataract surgery / J Cataract Refract Surg 21 : 710 ~ 713
Ghosh K / 2006 / Fibronectin functional domains coupled to hyaluronan stimulate adult human dermal fibroblast responses critical for wound healing / Tissue Eng 12 : 601 ~ 61
Heldin P / 1989 / Effect of growth factors on hyaluronan synthesis in cultured human fibroblasts / Biochem J 258 : 919 ~ 922
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