지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제23권 제6호
- 발행연도
- 2013.1
- 수록면
- 779 - 784 (6page)
이용수
초록· 키워드
오류제보하기
Leptospirosis is a worldwide zoonosis of global concern caused by Leptospira interrogans. The availability of ligand libraries has facilitated the search for novel drug targets using chemogenomics approaches, compared with the traditional method of drug discovery, which is time consuming and yields few leads with little intracellular information for guiding target selection. Recent subtractive genomics studies have revealed the putative drug targets in peptidoglycan biosynthesis pathways in Leptospira interrogans. Aligand library for the murD ligase enzyme in the peptidoglycan pathway has also been identified.
Our approach in this research involves screening of the pre-existing ligand library of murD with related protein family members in the putative drug target assembly in the peptidoglycan biosynthesis pathway. A chemogenomics approach has been implemented here, which involves screening of known ligands of a protein family having analogous domain architecture for identification of leads for existing druggable protein family members. By means of this approach, one murC and one murF inhibitor were identified, providing a platform for developing an antileptospirosis drug targeting the peptidoglycan biosynthesis pathway. Given that the peptidoglycan biosynthesis pathway is exclusive to bacteria, the in silico identified mur ligase inhibitors are expected to be broad-spectrum Gram-negative inhibitors if synthesized and tested in in vitro and in vivo assays.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Amineni, U. / 2010 / In silico identification of common putative drug targets in Leptospira interrogans / J. Chem. Biol 14 : 165 ~ 173
Amineni, U. / 2010 / Virtual screening for potential inhibitors of homology modeled Leptospira interrogans MurD ligase / J. Chem. Biol 3 : 3175 ~ 3187
Barreteau, H. / 2008 / Cytoplasmic steps of peptidoglycan biosynthesis / FEMS Microbiol. Rev 32 : 168 ~ 207
Bharti, A. R. / 2003 / Leptospirosis: A zoonotic disease of global importance / Lancet Infect. Dis 3 : 757 ~ 771
Bleicher, K. H. / 2002 / Chemogenomics: Bridging a drug discovery gap / Curr. Med. Chem 9 : 2077 ~ 2084
Amineni, U. / 2010 / Virtual screening for potential inhibitors of homology modeled Leptospira interrogans MurD ligase / J. Chem. Biol 3 : 3175 ~ 3187
Barreteau, H. / 2008 / Cytoplasmic steps of peptidoglycan biosynthesis / FEMS Microbiol. Rev 32 : 168 ~ 207
Bharti, A. R. / 2003 / Leptospirosis: A zoonotic disease of global importance / Lancet Infect. Dis 3 : 757 ~ 771
Bleicher, K. H. / 2002 / Chemogenomics: Bridging a drug discovery gap / Curr. Med. Chem 9 : 2077 ~ 2084
이 논문의 저자 정보
최근 본 자료
댓글(0)
0