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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제12호
- 발행연도
- 2012.1
- 수록면
- 1,790 - 1,794 (5page)
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Recently, it has been suggested that p27Kip1, the cell cycle regulatory protein, plays a pivotal role in the progression of normal differentiation in murine embryonic stem (mES) cells. In the current study, we investigated the role of p27Kip1 in the regulation of differentiation and apoptotic induction using Western blotting, quantitative real-time RT-PCR, and small interfering RNA (siRNA) assays and confocal laser scanning microscopic analysis of H9 human ES (hES) cells and H9-derived embryoid bodies (EBs)grown for 10 (EB10) and 20 days (EB20). Our results demonstrate that the proteins p27Kip1 and cyclin D3 are strongly associated with cellular differentiation, and, for the first time, show that up-regulation of p27Kip1 protects hES cells from inducing differentiation-associated and caspase 3-dependent apoptosis.
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참고문헌 (20)
참고문헌 신청
Bahrami, A. R. / 2005 / The CDK inhibitor p27 enhances neural differentiation in pluripotent NTERA2 human EC cells, but does not permit differentiation of 2102Ep nullipotent
Baldassarre, G. / 1999 / Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation / Oncogene 18 : 6241 ~ 2651
Baldassarre, G. / 2000 / Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhi
Boonen, G. J. J. C. / 1999 / Cyclin D3 regulates proliferation and apoptosis of leukemic T cell lines / J. Biol. Chem 274 : 34676 ~ 34682
Bryja, V. / 2004 / Increased apoptosis in differentiating p27- deficient embryonic stem cells / Cell. Mol. Life Sci 61 : 1384 ~ 1400
Baldassarre, G. / 1999 / Key role of the cyclin-dependent kinase inhibitor p27kip1 for embryonal carcinoma cell survival and differentiation / Oncogene 18 : 6241 ~ 2651
Baldassarre, G. / 2000 / Retinoic acid induces neuronal differentiation of embryonal carcinoma cells by reducing proteasome-dependent proteolysis of the cyclin-dependent inhi
Boonen, G. J. J. C. / 1999 / Cyclin D3 regulates proliferation and apoptosis of leukemic T cell lines / J. Biol. Chem 274 : 34676 ~ 34682
Bryja, V. / 2004 / Increased apoptosis in differentiating p27- deficient embryonic stem cells / Cell. Mol. Life Sci 61 : 1384 ~ 1400
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