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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제21권 제9호
- 발행연도
- 2011.1
- 수록면
- 903 - 913 (11page)
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초록· 키워드
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Vibrio parahaemolyticus, which causes gastroenteritis,wound infection, and septicemia, has two sets of type III secretion systems (TTSS), TTSS1 and TTSS2. A TTSS1-deficient vcrD1 mutant of V. parahaemolyticus showed an attenuated cytotoxicity against HEp-2 cells, and a significant reduction in mouse lethality, which were both restored by complementation with the intact vcrD1 gene. V.
parahaemolyticus also triggered phosphorylation of mitogenactivated protein kinases (MAPKs) including p38 and ERK1/2 in HEp-2 cells. The ability to activate p38 and ERK1/2 was significantly affected in a TTSS1-deficient vcrD1 mutant. Experiments using MAPK inhibitors showed that p38 and ERK1/2 MAPKs are involved in V.
parahaemolyticus-induced death of HEp-2 cells. In addition,caspase-3 and caspase-9 were processed into active forms in V. parahaemolyticus-exposed HEp-2 cells, but activation of caspases was not essential for V. parahaemolyticusinduced death of HEp-2 cells, as shown by both annexin V staining and lactate dehydrogenase release assays. We conclude that secreted protein(s) of TTSS1 play an important role in activation of p38 and ERK1/2 in HEp-2cells that eventually leads to cell death via a caspaseindependent mechanism.
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참고문헌 (23)
참고문헌 신청
Akeda, Y / 2009 / Identification and characterization of a type III secretion associated chaperone in the type III secretion system 1 of Vibrio parahaemolyticus / FEMS Microb
Belmorkhtar, C. A. / 2001 / Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms / Oncogene 20 : 3354 ~ 3362
Bhattacharjee, R. N / 2006 / VP1686, a Vibrio type III secretion protein, induces Toll-like receptor-independent apoptosis in macrophage through NF-kB inhibition / J. Biol. C
Burdette, D. L / 2009 / Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death / Autophagy 5 : 100 ~ 102
Burdette, D. L / 2009 / Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis / Mol. Microbiol 73 : 639 ~ 649
Belmorkhtar, C. A. / 2001 / Staurosporine induces apoptosis through both caspase-dependent and caspase-independent mechanisms / Oncogene 20 : 3354 ~ 3362
Bhattacharjee, R. N / 2006 / VP1686, a Vibrio type III secretion protein, induces Toll-like receptor-independent apoptosis in macrophage through NF-kB inhibition / J. Biol. C
Burdette, D. L / 2009 / Not without cause: Vibrio parahaemolyticus induces acute autophagy and cell death / Autophagy 5 : 100 ~ 102
Burdette, D. L / 2009 / Vibrio VopQ induces PI3-kinase-independent autophagy and antagonizes phagocytosis / Mol. Microbiol 73 : 639 ~ 649
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