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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제21권 제5호
- 발행연도
- 2011.1
- 수록면
- 449 - 454 (6page)
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초록· 키워드
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The infection of pandemic influenza viruses such as swine flu (H1N1) and avian flu viruses to the host cells is related to the following two factors: First, the surface protein such as HA (hemagglutinin) and NA (neuraminidase) of the influenza virus. Second, the specific structure of the oligosaccharide [sialic acid(α2-6) galactose(β1-4)glucose or sialic acid(α2-3)galactose(β1-4)glucose] on the host cell.
After recognizing the specific structure of the oligosaccharide on the surface of host cells by the surface protein of the influenza virus, the influenza virus can secrete sialidase and cleave the sialic acid attached on the final position of the specific structure of the oligosaccharide on the surface of host cells. Tamiflu (oseltamivir), known as a remedy of swine flu, has a saccharide analog structure, especially the sialic acid analog. Tamiflu can inhibit the invasion of influenza viruses (swine flu and avian flu viruses) into the host cells by competition with sialic acid on the terminal position of the specific oligosaccharide on the surface of the host cell. Because of the emergence of Tamiflu resistance, the development of new potent anti-influenza inhibitors is needed. The inhibitors with positive-charge groups have potential as antiviral therapeutics, and the strain specificity must also be resolved.
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참고문헌 (24)
참고문헌 신청
Amaro, R. E / 2007 / Remarkable loop flexibility in avian influenza N1 and its implications for antiviral drug design / J. Am. Chem. Soc 129 : 7764 ~ 7765
Aruksakunwong, O / 2007 / On the lower susceptibility of oseltamivir to influenza neuraminidase subtype N1 than those in N2 and N9 / Biophys. J 92 : 798 ~ 807
Babu, Y. S / 2000 / BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug de
Blick, T. J / 1998 / The interaction of neuraminidase and hemagglutinin mutations in influenza virus in resistance to 4-guanidino-Neu5Ac2en / Viology 246 : 95 ~ 103
Bradley,D / 2005 / Star role for bacteria in controlling flu pandemic / Nat. Rev. Drug Discov 4 : 945 ~ 946
Aruksakunwong, O / 2007 / On the lower susceptibility of oseltamivir to influenza neuraminidase subtype N1 than those in N2 and N9 / Biophys. J 92 : 798 ~ 807
Babu, Y. S / 2000 / BCX-1812 (RWJ-270201): Discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug de
Blick, T. J / 1998 / The interaction of neuraminidase and hemagglutinin mutations in influenza virus in resistance to 4-guanidino-Neu5Ac2en / Viology 246 : 95 ~ 103
Bradley,D / 2005 / Star role for bacteria in controlling flu pandemic / Nat. Rev. Drug Discov 4 : 945 ~ 946
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