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- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제21권 제3호
- 발행연도
- 2011.1
- 수록면
- 243 - 251 (9page)
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The gene bolA was discovered in the 80’s, but unraveling its function in the cell has proven to be a complex task.
The BolA protein has pleiotropic effects over cell physiology, altering growth and morphology, inducing biofilm formation, and regulating the balance of several membrane proteins. Recently, BolA was shown to be a transcription factor by repressing the expression of the mreB gene. The present report shows that BolA is a transcriptional regulator of the dacA and dacC genes, thus regulating both DD-carboxypeptidases PBP5 and PBP6and thereby demonstrating the versatility of BolA as a cellular regulator. In this work, we also demonstrate that reduction of cell growth and survival can be connected to the overexpression of the bolA gene in different E. coli backgrounds, particularly in the exponential growth phase. The most interesting finding is that overproduction of BolA affects bacterial growth differently depending on whether the cells were inoculated directly from a plate culture or from an overnight batch culture. This strengthens the idea that BolA can be engaged in the coordination of genes that adapt the cell physiology in order to enhance cell adaptation and survival under stress conditions.
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참고문헌 (23)
참고문헌 신청
Aldea, M / 1988 / Identification, cloning, and expression of bolA, an ftsZ-dependent morphogene of Escherichia coli / J. Bacteriol 170 : 5169 ~ 5176
Aldea, M / 1989 / Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene / EMBO J 8 : 3923 ~ 3931
Aldea, M / 1990 / Division genes in Escherichia coli are expressed coordinately to cell septum requirements by gearbox promoters / EMBO J 9 : 3787 ~ 3794
Bachmann, B. J / 1980 / Linkage map of Escherichia coli K-12, edition 6 / Microbiol. Rev 44 : 1 ~ 56
Barbas, A / 2008 / New insights into the mechanism of RNA degradation by ribonuclease II. Identification of the residue responsible for setting the RNase II end product / J.
Aldea, M / 1989 / Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene / EMBO J 8 : 3923 ~ 3931
Aldea, M / 1990 / Division genes in Escherichia coli are expressed coordinately to cell septum requirements by gearbox promoters / EMBO J 9 : 3787 ~ 3794
Bachmann, B. J / 1980 / Linkage map of Escherichia coli K-12, edition 6 / Microbiol. Rev 44 : 1 ~ 56
Barbas, A / 2008 / New insights into the mechanism of RNA degradation by ribonuclease II. Identification of the residue responsible for setting the RNase II end product / J.
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