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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제8호
- 발행연도
- 2018.1
- 수록면
- 1,247 - 1,259 (13page)
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초록· 키워드
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Raspberries are polyphenol-rich fruits with the potential to reduce the severity of the clinical signs associated with obesity, a phenomenon that may be related to changes in the gut microbiota. The aim of this study was to investigate the effect of raspberry supplementation on the fecal microbiota using an in vivo model of obesity. Obese diabetic db/db mice were used in this study and assigned to two experimental groups (with and without raspberry supplementation). Fecal samples were collected at the end of the supplementation period (8 weeks) and used for bacterial 16S rRNA gene profiling using a MiSeq instrument (Illumina). QIIME 1.8 was used to analyze the 16S data. Raspberry supplementation was associated with an increased abundance of Lachnospiraceae (p = 0.009), a very important group for gut health, and decreased abundances of Lactobacillus, Odoribacter, and the fiber degrader S24-7 family as well as unknown groups of Bacteroidales and Enterobacteriaceae (p < 0.05). These changes were enough to clearly differentiate bacterial communities accordingly to treatment, based on the analysis of UniFrac distance metrics. However, a predictive approach of functional profiles showed no difference between the treatment groups. Fecal metabolomic analysis provided critical information regarding the raspberry-supplemented group, whose relatively higher phytosterol concentrations may be relevant for the host health, considering the proven health benefits of these phytochemicals. Further studies are needed to investigate whether the observed differences in microbial communities (e.g., Lachnospiraceae) or metabolites relate to clinically significant differences that can prompt the use of raspberry extracts to help patients with obesity.
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등록된 정보가 없습니다.
참고문헌 (59)
참고문헌 신청
Zukiewicz-Sobczak W / 2014 / Obesity and poverty paradox in developed countries / Ann. Agric. Environ. Med. 21:590~594
Smith KB / 2016 / Obesity statistics / Prim. Care 43:121~135
Spieker EA / 2016 / Economic impact of obesity / Prim. Care 43:83~95
Subhan FB / 2016 / Review of dietary practices of the 21st century: facts and fallacies / Can. J. Diabetes 40:348~354
Clemente JC / 2012 / The impact of the gut microbiota on human health: an integrative view / Cell 148:1258~1270
Smith KB / 2016 / Obesity statistics / Prim. Care 43:121~135
Spieker EA / 2016 / Economic impact of obesity / Prim. Care 43:83~95
Subhan FB / 2016 / Review of dietary practices of the 21st century: facts and fallacies / Can. J. Diabetes 40:348~354
Clemente JC / 2012 / The impact of the gut microbiota on human health: an integrative view / Cell 148:1258~1270
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