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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제7호
- 발행연도
- 2018.1
- 수록면
- 1,199 - 1,208 (10page)
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초록· 키워드
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Osteoarthritis is a disease that affects the articular cartilage and osseous tissue, and can be worsened by aging, overweight status, and post-traumatic arthritis. The present study aimed to evaluate the effect of ID-CBT5101 (tyndallized Clostridium butyricum) on bone metabolism and the inflammatory response in a monosodium iodoacetate-induced rat model of osteoarthritis. ID-CBT5101 was administered orally at doses of 108 or 1010 CFU/day for 2 weeks before direct injection of monosodium iodoacetate (3 mg/50 μl of 0.9% saline) into the intra-articular space of the rats’ right knees. The rats subsequently received the same doses of oral ID-CBT5101 for another 4 weeks. We evaluated the treatment effects based on serum biomarkers, mRNA expression, morphological and histopathological analyses of the knee joints, and weight-bearing distribution analysis. Compared with those in control rats, the IDCBT5101 treatments significantly reduced the serum concentration of inflammation and bone metabolism markers (i.e., COX-2, IL-6, LTB4, and COMP), and significantly increased the concentration of IFN-γ and glycosaminoglycans. In addition, the ID-CBT5101 treatments inhibited the mRNA expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases (i.e., MMP-2, MMP-3, MMP-9, MMP-13, TIMP-1, and TIMP-2). Furthermore, the ID-CBT5101 treatments effectively preserved the knee cartilage and synovial membrane, and significantly decreased the amount of fibrous tissue. Moreover, compared with that of the negative control group, the ID-CBT5101 treatments increased the weight-bearing distribution by ≥20%. The results indicate that ID-CBT5101 prevented and alleviated osteoarthritis symptoms. Thus, ID-CBT5101 may be a novel therapeutic option for the management of osteoarthritis.
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참고문헌 (44)
참고문헌 신청
Pritzker KP / 2006 / Osteoarthritis cartilage histopathology: grading and staging / Osteoarthr. Cartil. 14:13~29
Longo UG / 2012 / Osteoarthritis: new insights in animal models / Open Orthop. J. 6:558~563
Couture RR / 1984 / Studies on the trigeminal antidromic vasodilatation and plasma extravasation in the rat / J. Physiol. 346:273~285
Brody LT / 2015 / Knee osteoarthritis: clinical connections to articular cartilage structure and function / Phys. Ther. Sport 16:301~316
박상욱 / 2014 / 퇴행성 관절염에 대한 HT008과 글루코사민의 유효성 및 안전성을 비교평가하기 위한 무작위 배정, 이중맹검 임상연구 / 대한본초학회지 29(4):45~52
Longo UG / 2012 / Osteoarthritis: new insights in animal models / Open Orthop. J. 6:558~563
Couture RR / 1984 / Studies on the trigeminal antidromic vasodilatation and plasma extravasation in the rat / J. Physiol. 346:273~285
Brody LT / 2015 / Knee osteoarthritis: clinical connections to articular cartilage structure and function / Phys. Ther. Sport 16:301~316
박상욱 / 2014 / 퇴행성 관절염에 대한 HT008과 글루코사민의 유효성 및 안전성을 비교평가하기 위한 무작위 배정, 이중맹검 임상연구 / 대한본초학회지 29(4):45~52
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