지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제23권 제8호
- 발행연도
- 2013.1
- 수록면
- 1,167 - 1,175 (9page)
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초록· 키워드
오류제보하기
Paratuberculosis (PTB) or Johne’s disease is one of the most serious chronic debilitating diseases of ruminants worldwide that is caused by Mycobacterium avium subsp. paratuberculosis (MAP). MAP is a slow-growing bacterium that has very long latent periods, resulting in difficulties in diagnosing and controlling the disease, especially regarding the diagnosis of fecal shedders of MAP without any clinical signs. Based on this situation, attempts were made to identify biomarkers that show early responses to MAP infection in a macrophage cell line,RAW 264.7. In response to the infection with the bacterium, a lot of genes were turned on and/or off in the cells. Of the altered genes, three different categories were identified based on the time-dependent gene expression patterns. Those genes were considered as possible candidates for biomarkers of MAP infection after confirmation by quantitative RT-PCR analysis. To the best of our knowledge, this is the first attempt at discovering the host transcriptomic biomarkers of PTB, although further investigation will be required to determine whether these biomarker candidates are associated within the natural host.
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참고문헌 (21)
참고문헌 신청
Bull TJ / 2003 / Detection and verification of Mycobacterium avium subsp. paratuberculosis in fresh ileocolonic mucosal biopsy specimens from individuals with and without Cro
Coussens PM / 2004 / Rapid and transient activation of gene expression in peripheral blood mononuclear cells from Johne's disease positive cows exposed to Mycobacterium parat
Diel R / 2008 / Predictive value of a whole blood IFN-γ assay for the development of active tuberculosis disease after recent infection with Mycobacterium tuberculosis / Am.
Essaghir A / 2012 / A minimal connected network of transcription factors regulated in human tumors and its application to the quest for universal cancer biomarkers / PLoS One
Gold DV / 2011 / Enhanced expression of CD74 in gastrointestinal cancers and benign tissues / Int. J. Clin. Exp. Pathol 4 : 1 ~ 12
Coussens PM / 2004 / Rapid and transient activation of gene expression in peripheral blood mononuclear cells from Johne's disease positive cows exposed to Mycobacterium parat
Diel R / 2008 / Predictive value of a whole blood IFN-γ assay for the development of active tuberculosis disease after recent infection with Mycobacterium tuberculosis / Am.
Essaghir A / 2012 / A minimal connected network of transcription factors regulated in human tumors and its application to the quest for universal cancer biomarkers / PLoS One
Gold DV / 2011 / Enhanced expression of CD74 in gastrointestinal cancers and benign tissues / Int. J. Clin. Exp. Pathol 4 : 1 ~ 12
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