지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제3호
- 발행연도
- 2012.1
- 수록면
- 422 - 430 (9page)
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초록· 키워드
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Previous studies have demonstrated that repeated restraint stress in rodents produces increases in depression and anxietylike behaviors and alters the expression of corticotrophinreleasing factor (CRF) in the hypothalamus. The current study focused on the impact of Bupleurum falcatum (BF)extract administration on repeated restraint stress-induced behavioral responses using the forced swimming test (FST)and elevated plus maze (EPM) test. Immunohistochemical examinations of tyrosine hydroxylase (TH) expression in rat brain were also conducted. Male rats received daily doses of 20, 50, or 100 mg/kg (i.p.) BF extract for 15 days,30 min prior to restraint stress (4 h/day). Hypothalamicpituitary-adrenal axis activation in response to repeated restraint stress was confirmed base on serum corticosterone levels and CRF expression in the hypothalamus. Animals that were pre-treated with BF extract displayed significantly reduced immobility in the FST and increased open-arm exploration in the EPM test in comparison with controls.
BF also blocked the increase in TH expression in the locus coeruleus of treated rats that experienced restraint stress.
Together, these results demonstrate that BF extract administration prior to restraint stress significantly reduces depression and anxiety-like behaviors, possibly through central adrenergic mechanisms, and they suggest a role for BF extract in the treatment of depression and anxiety disorders.
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참고문헌 (22)
참고문헌 신청
Bravo, J. A. / 2009 / Desipramine prevents stressinduced changes in depressive-like behavior and hippocampal markers of neuroprotection / Behav. Pharmacol 20 : 273 ~ 285
Checkley, S. / 1996 / The neuroendocrinology of depression and chronic stress / Br. Med. Bull 52 : 597 ~ 617
Chotiwat, C. / 2008 / Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats / Am. J. Physiol. Regul. Int
Chotiwat, C. / 2010 / The effects of repeated restraint stress on energy balance and behavior of mice with selective deletion of CRF receptors / Stress 13 : 203 ~ 213
Cryan, J. F. / 2005 / The ascent of mouse: Advances in modelling human depression and anxiety / Nat. Rev. Drug Discov 4 : 775 ~ 790
Checkley, S. / 1996 / The neuroendocrinology of depression and chronic stress / Br. Med. Bull 52 : 597 ~ 617
Chotiwat, C. / 2008 / Antagonism of specific corticotropin-releasing factor receptor subtypes selectively modifies weight loss in restrained rats / Am. J. Physiol. Regul. Int
Chotiwat, C. / 2010 / The effects of repeated restraint stress on energy balance and behavior of mice with selective deletion of CRF receptors / Stress 13 : 203 ~ 213
Cryan, J. F. / 2005 / The ascent of mouse: Advances in modelling human depression and anxiety / Nat. Rev. Drug Discov 4 : 775 ~ 790
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