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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제24권 제9호
- 발행연도
- 2014.1
- 수록면
- 1,291 - 1,299 (9page)
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Recently, multifunctional nanomaterials have been developed as nanotherapeutic agents for cellular imaging and targeted cancer treatment because of their ease of synthesis and low cytotoxicity. In this study, we developed a multifunctional, two-component nanorod consisting of gold (Au) and nickel (Ni) blocks that enables dual-fluorescence imaging and the targeted delivery of small interfering RNA (siRNA) to improve cancer treatment. Fluorescein isothiocyanate-labeled luteinizing hormone-releasing hormone (LHRH) peptides were attached to the surface of a Ni block via a histidine-tagged LHRH interaction to specifically bind to a breast cancer cell line, MCF-7. The Au block was modified with TAMRA-labeled thiolated siRNA in order to knock down the vascular endothelial growth factor protein to inhibit cancer growth. These two-component nanorods actively targeted and internalized into MCF-7 cells to induce apoptosis through RNA interference. This study demonstrates the feasibility of using two-component nanorods as a potential theranostic in breast cancer treatment, with capabilities in dual imaging and targeted gene delivery.
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참고문헌 (26)
참고문헌 신청
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Agarwal G / 2003 / Immobilization of histidine-tagged proteins on nickel by electrochemical dip pen nanolithography / J. Am. Chem. Soc 125 : 7408 ~ 7412
Bhattacharyya S / 2011 / Inorganic nanoparticles in cancer therapy / Pharm. Res 28 : 237 ~ 259
Byrne JD / 2008 / Active targeting schemes for nanoparticle systems in cancer therapeutics / Adv. Drug Deliv. Rev 60 : 1615 ~ 1626
Chakravarty P / 2008 / Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes / Proc. Natl. Acad. Sci. USA 105 : 8697 ~ 8702
Agarwal G / 2003 / Immobilization of histidine-tagged proteins on nickel by electrochemical dip pen nanolithography / J. Am. Chem. Soc 125 : 7408 ~ 7412
Bhattacharyya S / 2011 / Inorganic nanoparticles in cancer therapy / Pharm. Res 28 : 237 ~ 259
Byrne JD / 2008 / Active targeting schemes for nanoparticle systems in cancer therapeutics / Adv. Drug Deliv. Rev 60 : 1615 ~ 1626
Chakravarty P / 2008 / Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes / Proc. Natl. Acad. Sci. USA 105 : 8697 ~ 8702
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