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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제23권 제1호
- 발행연도
- 2013.1
- 수록면
- 118 - 124 (7page)
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Vibrio parahaemolyticus in uncooked seafood causes acute gastroenteritis. The microorganism has two sets of type III secretion systems and two hemolysins. When it injects its effector proteins into a host cell via type III secretion system 1, one of the type III secretion systems induces secretion of interleukin (IL)-8, a proinflammatory chemokine,through the phosphorylation of ERK 1/2 and p38 MAPK.
Although probiotics have beneficial effects on hosts and can help control some infectious diseases, there is little research on the efficacy of probiotics in V. parahaemolyticus infection. Here we pretreated V. parahaemolyticus-infected human intestinal epithelial cells with heat-killed Lactobacillus brevis KB290, a probiotic isolated from fermented vegetables (traditional Japanese pickles) and utilized as an ingredient of beverages and supplementary foods, and demonstrated its efficacy in enhancing IL-8 secretion from V.
parahaemolyticus-infected cells. Among the three heat-killed lactic acid bacterial strains we tested, L. brevis KB290induced the highest level of IL-8 secretions in the infected cells. Relative to control cells (Caco-2 cells pretreated with PBS), V. parahaemolyticus-infected Caco-2 cells pretreated with heat-killed L. brevis KB290 secreted IL-8 earlier,although concentrations were similar 450min after infection.
Heat-killed L. brevis KB290 pretreatment also induced earlier ERK 1/2 phosphorylation, greater p38 MAPK phosphorylation, and enhanced IL-8 mRNA expression.
Heat-killed L. brevis KB290 accelerated IL-8 secretion, a host cell immune response, in V. parahaemolyticus-infected cells. We consider this to be beneficial because IL-8 plays an important defensive role against infection, and would contribute to the repair of injured epithelial cells.
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참고문헌 (23)
참고문헌 신청
Corr, S. C / 2007 / Impact of selected Lactobacillus and Bifidobacterium species on Listeria monocytogenes infection and the mucosal immune response / FEMS Immunol. Med. Micr
Dai, C / 2012 / VSL#3 probiotics regulate the intestinal epithelial barrier in vivo and in vitro via the p38 and ERK signaling pathways / Int. J. Mol. Med 29 : 202 ~ 208
Edwards, L. A / 2011 / Bacterial-epithelial contact is a key determinant of host innate immune responses to enteropathogenic and enteroaggregative Escherichia coli / PLoS One
FAO/WHO / 2011 / Risk assessment of Vibrio parahaemolyticus in seafood: Interpretative summary and technical report
FAO/WHO Codex Alimentarius / 2010 / Guidelines on the application of general principles of food hygiene to the control of pathogenic Vibrio species in seafood / CAC/GL 73-2010
Dai, C / 2012 / VSL#3 probiotics regulate the intestinal epithelial barrier in vivo and in vitro via the p38 and ERK signaling pathways / Int. J. Mol. Med 29 : 202 ~ 208
Edwards, L. A / 2011 / Bacterial-epithelial contact is a key determinant of host innate immune responses to enteropathogenic and enteroaggregative Escherichia coli / PLoS One
FAO/WHO / 2011 / Risk assessment of Vibrio parahaemolyticus in seafood: Interpretative summary and technical report
FAO/WHO Codex Alimentarius / 2010 / Guidelines on the application of general principles of food hygiene to the control of pathogenic Vibrio species in seafood / CAC/GL 73-2010
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