개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제23권 제1호
- 발행연도
- 2013.1
- 수록면
- 125 - 130 (6page)
이용수
초록· 키워드
오류제보하기
Influenza viruses cause significant morbidity and mortality in humans through epidemics or pandemics. Currently,two classes of anti-influenza virus drugs, M2 ion-channel inhibitors (amantadin and rimantadine) and neuraminidase inhibitors (oseltamivir and zanamivir), have been used for the treatment of the influenza virus infection. Since the resistance to these drugs has been reported, the development of a new antiviral agent is necessary. In this study, we examined the antiviral efficacy of the plant extracts against the influenza A/PR/8/34 infection. In vitro, the antiviral activities of the plant extracts were investigated using the cell-based screening. Three plant extracts, Thuja orientalis, Aster spathulifolius, and Pinus thunbergii, were shown to induce a high cell viability rate after the infection with the influenza A/PR/8/34 virus. The antiviral activity of the plant extracts also increased as a function of the concentration of the extracts and these extracts significantly reduced the visible cytopathic effect caused by virus infections. Furthermore, the treatment with T. orientalis was shown to have a stronger inhibitory effect than that with A. spathulifolius or P. thunbergii. These results may suggest that T. orientalis has anti-influenza A/PR/8/34 activity.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bright, R. A / 2006 / Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States / JAMA 295 : 891 ~ 894
CDC / 2009 / Effectiveness of 2008-09 trivalent influenza vaccine against 2009 pandemic influenza A (H1N1) - United States, May-June 2009 / Morb. Mortal. Wkly. Rep 58
Cassetti, M. C / 2005 / Report of meeting on the development of influenza vaccines with broad spectrum and long-lasting immune responses, World Health Organization, Geneva, S
Choi, H. J / 2009 / Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication / Eur. J. Pharm. Sci 37 : 329 ~ 333
Chomczynski, P / 1987 / Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction / Anal. Biochem 162 : 156 ~ 159
CDC / 2009 / Effectiveness of 2008-09 trivalent influenza vaccine against 2009 pandemic influenza A (H1N1) - United States, May-June 2009 / Morb. Mortal. Wkly. Rep 58
Cassetti, M. C / 2005 / Report of meeting on the development of influenza vaccines with broad spectrum and long-lasting immune responses, World Health Organization, Geneva, S
Choi, H. J / 2009 / Inhibitory effects of quercetin 3-rhamnoside on influenza A virus replication / Eur. J. Pharm. Sci 37 : 329 ~ 333
Chomczynski, P / 1987 / Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction / Anal. Biochem 162 : 156 ~ 159
이 논문의 저자 정보
최근 본 자료
댓글(0)
0