지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제6호
- 발행연도
- 2012.1
- 수록면
- 806 - 813 (8page)
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초록· 키워드
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Adipocyte differentiation is strongly associated with obesity, which causes metabolic disorders. In this study,we investigated the inhibitory effects of widdrol on 3T3-L1 preadipocyte growth and differentiation. Widdrol decreased lipid droplet accumulation and down-regulated adipogenic transcription factors such as C/EBPα, C/EBPβ,and PPARγ. Widdrol blocked preadipocyte proliferation and differentiation through the inhibition of mitotic clonal expansion, which was accompanied by the failure of degradation of p21, a cyclin-dependent kinase inhibitor.
Cell-cycle analysis clearly indicated that widdrol actively induces cell-cycle arrest at the G1-S phage transition,causing cells to remain in the preadipocyte state. Moreover,widdrol increased p21 expression and inhibited Rb phosphorylation in preadipocyte incubated in a hormone medium. Therefore, these findings clearly suggest that widdrol blocks preadipocyte growth and differentiation through the inhibition of mitotic clonal expansion by p21-and Rb-dependent G1 arrest and can be developed as a potent anti-adipogenic agent for reducing obesity.
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참고문헌 (25)
참고문헌 신청
Bray, G. A. / 2000 / Medicinal strategies in the treatment of obesity / Nature 404 : 672 ~ 677
Caro, J. F. / 1989 / Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes / Diab. Metab. Rev
Cornelius, P. / 1994 / Regulation of adipocyte development / Annu. Rev. Nutr 14 : 99 ~ 129
Couillard, C. / 2000 / Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia / Int. J. Obes. Relat. Metab. Disord 24 :
DeGregori, J. / 2004 / The Rb network / J. Cell Sci 117 : 3411 ~ 3413
Caro, J. F. / 1989 / Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes / Diab. Metab. Rev
Cornelius, P. / 1994 / Regulation of adipocyte development / Annu. Rev. Nutr 14 : 99 ~ 129
Couillard, C. / 2000 / Hyperleptinemia is more closely associated with adipose cell hypertrophy than with adipose tissue hyperplasia / Int. J. Obes. Relat. Metab. Disord 24 :
DeGregori, J. / 2004 / The Rb network / J. Cell Sci 117 : 3411 ~ 3413
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