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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제6호
- 발행연도
- 2012.1
- 수록면
- 800 - 805 (6page)
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초록· 키워드
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Licochalcone E was firstly isolated from licorice root in 2005, which belongs to the retrochalcone family. Studies on the biological activities of licochalcone E were in the initial stage. In the study, we demonstrated that licochalcone E has potent antimicrobial property against Staphylococcus aureus. Furthermore, via hemolysis, Western blot, and real-time RT-PCR assays, we have shown that subinhibitory concentrations of licochalcone E dosedependently reduces the production of α-toxin in both methicillin-sensitive S. aureus (MSSA) and methicillinresistant S. aureus (MRSA). The data suggest that licochalcone E may deserve further investigation as a potential therapeutic against S. aureus infections, or the structure of licochalcone E may be used as a basis for chemical synthesis of novel anti-S. aureus compounds.
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참고문헌 (23)
참고문헌 신청
Baltina, L. A. / 2003 / Chemical modification of glycyrrhizic acid as a route to new bioactive compounds for medicine / Curr. Med. Chem 10 : 155 ~ 171
Bhakdi, S. / 1991 / Alpha-toxin of Staphylococcus aureus / Microbiol. Rev 55 : 733 ~ 751
Chan, P. F. / 1998 / Role of SarA in virulence determinant production and environmental signal transduction in Staphylococcus aureus / J. Bacteriol 180 : 6232 ~ 6241
Chang, H. J. / 2007 / Induction of apoptosis by the licochalcone E in endothelial cells via modulation of NF-kappaB and Bcl-2 family / Biol. Pharm. Bull 30 : 2290 ~ 2293
Fu, Y. / 2004 / Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra),causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer
Bhakdi, S. / 1991 / Alpha-toxin of Staphylococcus aureus / Microbiol. Rev 55 : 733 ~ 751
Chan, P. F. / 1998 / Role of SarA in virulence determinant production and environmental signal transduction in Staphylococcus aureus / J. Bacteriol 180 : 6232 ~ 6241
Chang, H. J. / 2007 / Induction of apoptosis by the licochalcone E in endothelial cells via modulation of NF-kappaB and Bcl-2 family / Biol. Pharm. Bull 30 : 2290 ~ 2293
Fu, Y. / 2004 / Licochalcone-A, a novel flavonoid isolated from licorice root (Glycyrrhiza glabra),causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer
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