지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제22권 제6호
- 발행연도
- 2012.1
- 수록면
- 788 - 792 (5page)
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초록· 키워드
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We report the computational structural simulation of the Cry1Ab19 toxin molecule from B. thuringiensis BtX-2based on the structure of Cry1Aa1 deduced by x-ray diffraction. Validation results showed that 93.5% of modeled residues are folded in a favorable orientation with a total energy Z-score of -8.32, and the constructed model has an RMSD of only 1.13Å. The major differences in the presented model are longer loop lengths and shortened sheet components. The overall result supports the hierarchical three-domain structural hypothesis of Cry toxins and will help in better understanding the structural variation within the Cry toxin family along with facilitating the design of domain-swapping experiments aimed at improving the toxicity of native toxins.
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참고문헌 (19)
참고문헌 신청
Boonserm, P. / 2005 / Crystal structure of the mosquito-larvicidal toxin Cry4Ba and its biological implications / J. Mol. Biol 348 : 363 ~ 382
Boonserm, P. / 2006 / Structure of the functional form of the mosquito larvicidalCry4Aa toxin from Bacillus thuringiensis at a 2.8-angstromresolution / J. Bacteriol 188 : 339
Chen, X. J. / 1993 / Site-directed mutations in a highly conserved region of Bacillus thuringiensis δ-endotoxin affect inhibition of short circuit current across Bombyx mori
Derbyshire, D. J. / 2001 / Crystallization of the Bacillus thuringiensis toxin Cry1Ac and its complex with the receptor ligand N-acetyl-D-galactosamine / Acta Crystallogr. D
Galitsky, N. / 2001 / Structure of the insecticidal bacterial δ-endotoxin Cry3Bb1 of Bacillus thuringiensis / Acta Crystallogr. D 57 : 1101 ~ 1109
Boonserm, P. / 2006 / Structure of the functional form of the mosquito larvicidalCry4Aa toxin from Bacillus thuringiensis at a 2.8-angstromresolution / J. Bacteriol 188 : 339
Chen, X. J. / 1993 / Site-directed mutations in a highly conserved region of Bacillus thuringiensis δ-endotoxin affect inhibition of short circuit current across Bombyx mori
Derbyshire, D. J. / 2001 / Crystallization of the Bacillus thuringiensis toxin Cry1Ac and its complex with the receptor ligand N-acetyl-D-galactosamine / Acta Crystallogr. D
Galitsky, N. / 2001 / Structure of the insecticidal bacterial δ-endotoxin Cry3Bb1 of Bacillus thuringiensis / Acta Crystallogr. D 57 : 1101 ~ 1109
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