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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제6호
- 발행연도
- 2015.1
- 수록면
- 936 - 940 (5page)
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초록· 키워드
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Human papillomavirus (HPV) type 52 is a high-risk HPV responsible for cervical cancer. HPV type 52 is common around the world and is the most common in some Asian regions. The available prophylactic HPV vaccines protect only from HPV types 16 and 18. Supplementing economical vaccines that target HPV type 52 may satisfactorily complement available prophylactic vaccines. A codon-adapted HPV 52 L1 gene was expressed in the methylotrophic yeast Hansenula polymorpha, which is used as an industrial platform for economical hepatitis B surface antigen particle production in China. We found that the recombinant proteins produced in this expression system could form virus-like particles (VLPs) with diameters of approximately 50 nm. This study suggests that the HPV 52 VLPs produced in this platform may satisfactorily complement available prophylactic vaccines in fighting against HPVs prevalent in Asia.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Bian G / 2009 / Whole recombinant Hansenula polymorpha expressing hepatitis B virus surface antigen (yeast-HSsAg) induces potent HBsAg-specific Th1 and Th2 immune responses /
Bruni L / 2010 / Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings / J. Infect. Dis 202 : 1789 ~ 179
Chen Q / 2012 / Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China / PLoS One 7 : e32149 ~
Chui SH / 2012 / Human papillomavirus infection in Macau women / Public Health 126 : 600 ~ 604
D iminsky D / 1997 / Comparison between hepatitis B surface antigen (HBsAg)particles derived from mammalian cells (CHO) and yeast cells (Hansenula polymorpha): composition, s
Bruni L / 2010 / Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings / J. Infect. Dis 202 : 1789 ~ 179
Chen Q / 2012 / Epidemiologic characterization of human papillomavirus infection in rural Chaozhou, eastern Guangdong Province of China / PLoS One 7 : e32149 ~
Chui SH / 2012 / Human papillomavirus infection in Macau women / Public Health 126 : 600 ~ 604
D iminsky D / 1997 / Comparison between hepatitis B surface antigen (HBsAg)particles derived from mammalian cells (CHO) and yeast cells (Hansenula polymorpha): composition, s
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