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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제6호
- 발행연도
- 2015.1
- 수록면
- 863 - 871 (9page)
이용수
초록· 키워드
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Bifidobacterium longum subsp. longum BBMN68, isolated from centenarians in Guangxi, China, has been proved to be a promising probiotic strain for its health benefits. In this study, the biodistribution of this strain in the rat gut was first investigated using the quantitative realtime PCR assay and propidium monoazide. Strain-specific primers were originally designed based on the BBMN68 genome sequence. Healthy rats were orally inoculated with either a single dose of BBMN68 (1010 colony-forming units/kg), or with one dose per day for 7 days and bacterial concentrations were analyzed in detail from the intestinal contents and feces of four different gut locations, including stomach, small intestine, colon, and rectum. Results indicated that strain BBMN68 could overcome the rigors of passage through the upper gastrointestinal tract and transiently accumulate in the colon, even though survival in the stomach and small intestine was not high. A good level of BBMN8 could stay in vivo for 72 h following a 7-day oral administration, and a daily administration is suggested for a considerable and continuous population of BBMN68 to be maintained in the host intestine.
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참고문헌 (21)
참고문헌 신청
Ahlroos T / 2009 / Quantitative strain-specific detection of Lactobacillus rhamnosus GG in human faecal samples by real-time PCR / J. Appl. Microbiol 106 : 506 ~ 514
Annan N / 2008 / Encapsulation in alginate-coated gelatin microspheres improves survival of the probiotic Bifidobacterium adolescentis 15703T during exposure to simulated gas
Arakawa A / 1975 / Reduction of Clostridium perfringens by feed additive antibiotics in ceca of chickens infected with Eimeria tenella / Poult. Sci 54 : 1000 ~ 1007
Charteris W / 1998 / Development and application of an in vitro methodology to determine the transit tolerance of potentially probiotic Lactobacillus and Bifidobacterium spec
Conway PL / 1987 / Survival of lactic-acid bacteria in the human stomach and adhesion to intestinal-cells / J. Dairy Sci 70 : 1 ~ 12
Annan N / 2008 / Encapsulation in alginate-coated gelatin microspheres improves survival of the probiotic Bifidobacterium adolescentis 15703T during exposure to simulated gas
Arakawa A / 1975 / Reduction of Clostridium perfringens by feed additive antibiotics in ceca of chickens infected with Eimeria tenella / Poult. Sci 54 : 1000 ~ 1007
Charteris W / 1998 / Development and application of an in vitro methodology to determine the transit tolerance of potentially probiotic Lactobacillus and Bifidobacterium spec
Conway PL / 1987 / Survival of lactic-acid bacteria in the human stomach and adhesion to intestinal-cells / J. Dairy Sci 70 : 1 ~ 12
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